A1 Journal article (refereed)
Association between arterial health and cognition in adolescents : The PANIC study (2024)

Jalanko, P., Bond, B., Laukkanen, J., Brage, S., Ekelund, U., Laitinen, T., Määttä, S., Kähönen, M., Haapala, E., & Lakka, T. A. (2024). Association between arterial health and cognition in adolescents : The PANIC study. Physiological Reports, 12(9), Article e16024. https://doi.org/10.14814/phy2.16024

JYU authors or editors

Publication details

All authors or editors: Jalanko, Petri; Bond, Bert; Laukkanen, Jari, A.; Brage, Soren; Ekelund, Ulf; Laitinen, Tomi; Määttä, Sara; Kähönen, Mika; Haapala, Eero, A.; Lakka, Timo A.

Journal or series: Physiological Reports

eISSN: 2051-817X

Publication year: 2024

Publication date: 02/05/2024

Volume: 12

Issue number: 9

Article number: e16024

Publisher: Wiley

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.14814/phy2.16024

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/94872

Publication is parallel published: https://www.repository.cam.ac.uk/handle/1810/367922

Abstract

We investigated the associations of the measures of arterial health with cognition in adolescents and whether physical activity (PA) or sedentary time (ST) confounds these associations. One hundred sixteen adolescents (71 boys) aged 15.9 ± 0.4 participated in the study. PA and ST were assessed using a combined accelerometer/heart rate monitor. Overall cognition was computed from the results of psychomotor function, attention, working memory, and paired-associate learning tests. Pulse wave velocity was measured by impedance cardiography, carotid intima-media thickness, and carotid artery distensibility by carotid ultrasonography. Systolic and diastolic blood pressure (SBP and DBP) were measured using an aneroid sphygmomanometer. SBP was inversely associated with overall cognition (standardized regression coefficient [β] = −0.216, 95% confidence interval (CI) −0.406 to −0.027, p = 0.025). Pulse wave velocity (β = −0.199, 95% CI −0.382 to −0.017, p = 0.033) was inversely associated with working memory task accuracy. SBP was directly associated with reaction time in the attention (β = 0.256, 95% CI 0.069 to 0.443, p = 0.008) and errors in the paired-associate learning tasks (β = 0.308, 95% CI 0.126 to 0.489, p = 0.001). Blood pressure was inversely associated with overall cognition. PA or ST did not confound the associations. Results suggest that preventing high blood pressure is important for promoting cognition in adolescents.

Keywords: circulatory system; arteries; blood pressure; physical activity; physical fitness; immobility; cognitive development; young people

Contributing organizations

Ministry reporting: Yes

Reporting Year: 2024

Preliminary JUFO rating: 1