A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Exaggerated sensitivity to threat and reduced medial prefrontal engagement during threat generalization in reactive aggressive adolescents (2024)

Wang, Y., Becker, B., Wang, J., Wang, Y., Zhang, L., Mei, Y., Li, H., & Lei, Y. (2024). Exaggerated sensitivity to threat and reduced medial prefrontal engagement during threat generalization in reactive aggressive adolescents. Neuroimage, 294, Article 120645. https://doi.org/10.1016/j.neuroimage.2024.120645

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Wang, Yizhen; Becker, Benjamin; Wang, Jinxia; Wang, Yuanyuan; Zhang, Liangyou; Mei, Ying; Li, Hong; Lei, Yi

Lehti tai sarja: Neuroimage

ISSN: 1053-8119

eISSN: 1095-9572

Julkaisuvuosi: 2024

Ilmestymispäivä: 10.05.2024

Volyymi: 294

Artikkelinumero: 120645

Kustantaja: Elsevier

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1016/j.neuroimage.2024.120645

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/95130

Tiivistelmä

Aggressive adolescents tend to exhibit abnormal fear acquisition and extinction, and reactive aggressive adolescents are often more anxious. However, the relationship between fear generalization and reactive aggression (RA) remains unknown. According to Reactive-Proactive Aggression Questionnaire (RPQ) scores, 61 adolescents were divided into two groups, namely, a high RA group (N = 30) and a low aggression (LA) group (N = 31). All participants underwent three consecutive phases of the Pavlovian conditioning paradigm (i.e., habituation, acquisition, and generalization), and neural activation of the medial prefrontal cortex (mPFC) was assessed by functional near-infrared spectroscopy (fNIRS). The stimuli were ten circles with varying sizes, including two conditioned stimuli (CSs) and eight generalization stimuli (GSs). A scream at 85 dB served as the auditory unconditioned stimulus (US). The US expectancy ratings of both CSs and GSs were higher in the RA group than in the LA group. The fNIRS results showed that CSs and GSs evoked lower mPFC activation in the RA group compared to the LA group during fear generalization. These findings suggest that abnormalities in fear acquisition and generalization are prototypical dysregulations in adolescents with RA. They provide neurocognitive evidence for dysregulated fear learning in the mechanisms underlying adolescents with RA, highlighting the need to develop emotional regulation interventions for these individuals.

YSO-asiasanat: aggressiivisuus; nuoret; tunteet; pelko; ehdollistaminen; nuorisopsykologia; neuropsykologia; aivotutkimus

Vapaat asiasanat: reactive aggression; adolescence; fear generalization; fNIRS; mPFC

Liittyvät organisaatiot

OKM-raportointi: Kyllä

VIRTA-lähetysvuosi: 2024

Alustava JUFO-taso: 3