A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
The brain insulin receptor gene network and associations with frailty index (2024)
Selenius, J. S., Silveira, P. P., Haapanen, M. J., von Bonsdorff, M., Lahti, J., Eriksson, J. G., & Wasenius, N. S. (2024). The brain insulin receptor gene network and associations with frailty index. Age and Ageing, 53(5), Article afae091. https://doi.org/10.1093/ageing/afae091
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Selenius, Jannica S.; Silveira, Patricia P.; Haapanen, Markus J.; von Bonsdorff, Mikaela; Lahti, Jari; Eriksson, Johan G.; Wasenius, Niko S.
Lehti tai sarja: Age and Ageing
ISSN: 0002-0729
eISSN: 1468-2834
Julkaisuvuosi: 2024
Ilmestymispäivä: 16.05.2024
Volyymi: 53
Lehden numero: 5
Artikkelinumero: afae091
Kustantaja: Oxford University Press
Julkaisumaa: Britannia
Julkaisun kieli: englanti
DOI: https://doi.org/10.1093/ageing/afae091
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/95327
Tiivistelmä
Methods: This longitudinal study included 1605 participants from the Helsinki Birth Cohort Study. Biologically informed expression-based polygenic risk scores for the insulin receptor gene network, which measure genetic variation in the function of the insulin receptor, were calculated for the hippocampal (hePRS-IR) and the mesocorticolimbic (mePRS-IR) regions. Frailty was assessed in at baseline in 2001–2004, 2011–2013 and 2017–2018 by applying a deficit accumulation-based frailty index. Analyses were carried out by applying linear mixed models and logistical regression models adjusted for adult socioeconomic status, birthweight, smoking and their interactions with age.
Results: The FI levels of women were 1.19%-points (95% CI 0.12–2.26, P = 0.029) higher than in men. Both categorical and continuous hePRS-IR in women were associated with higher FI levels than in men at baseline (P < 0.05). In women with high hePRS-IR, the rate of change was steeper with increasing age compared to those with low or moderate hePRS-IR (P < 0.05). No associations were detected between mePRS-IR and frailty at baseline, nor between mePRS-IR and the increasein mean FI levels per year in either sex (P > 0.43).
Conclusions: Higher variation in the function of the insulin receptor gene network in the hippocampus is associated with increasing frailty in women. This could potentially offer novel targets for future drug development aimed at frailty and ageing.
YSO-asiasanat: ikääntyneet; ikääntyminen; insuliini; reseptorit (biokemia); geenit; hippokampus; gerastenia; pitkittäistutkimus
Vapaat asiasanat: insulin receptor (IR); frailty; hippocampal (hePRS); frailty index (FI); insulin receptor; older people
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2024
Alustava JUFO-taso: 3
