A2 Katsausartikkeli tieteellisessä aikausilehdessä
Antimicrobial resistance in the wild : Insights from epigenetics (2024)

Villalba de la Peña, M., & Kronholm, I. (2024). Antimicrobial resistance in the wild : Insights from epigenetics. Evolutionary Applications, 17(6), Article e13707. https://doi.org/10.1111/eva.13707

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Villalba de la Peña, Mariana; Kronholm, Ilkka

Lehti tai sarja: Evolutionary Applications

eISSN: 1752-4571

Julkaisuvuosi: 2024

Ilmestymispäivä: 29.05.2024

Volyymi: 17

Lehden numero: 6

Artikkelinumero: e13707

Kustantaja: Wiley

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1111/eva.13707

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/95575

Tiivistelmä

Spreading of bacterial and fungal strains that are resistant to antimicrobials poses a serious threat to the well-being of humans, animals, and plants. Antimicrobial resistance has been mainly investigated in clinical settings. However, throughout their evolutionary history microorganisms in the wild have encountered antimicrobial substances, forcing them to evolve strategies to combat antimicrobial action. It is well known that many of these strategies are based on genetic mechanisms, but these do not fully explain important aspects of the antimicrobial response such as the rapid development of resistance, reversible phenotypes, and hetero-resistance. Consequently, attention has turned toward epigenetic pathways that may offer additional insights into antimicrobial mechanisms. The aim of this review is to explore the epigenetic mechanisms that confer antimicrobial resistance, focusing on those that might be relevant for resistance in the wild. First, we examine the presence of antimicrobials in natural settings. Then we describe the documented epigenetic mechanisms in bacteria and fungi associated with antimicrobial resistance and discuss innovative epigenetic editing techniques to establish causality in this context. Finally, we discuss the relevance of these epigenetic mechanisms on the evolutionary dynamics of antimicrobial resistance in the wild, emphasizing the critical role of priming in the adaptation process. We underscore the necessity of incorporating non-genetic mechanisms into our understanding of antimicrobial resistance evolution. These mechanisms offer invaluable insights into the dynamics of antimicrobial adaptation within natural ecosystems.

YSO-asiasanat: epigenetiikka; sopeutuminen; mikrobit; antimikrobiset yhdisteet; resistenssi; luonnonympäristö; bakteerit; sienet

Vapaat asiasanat: adaptation; antimicrobial resistance; epigenetics; microbes; natural environment

Liittyvät organisaatiot

Hankkeet, joissa julkaisu on tehty

OKM-raportointi: Kyllä

VIRTA-lähetysvuosi: 2024

Alustava JUFO-taso: 2