A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Establishing Criteria for Tumor Necrosis as Prognostic Indicator in Colorectal Cancer (2024)
Kastinen, M., Sirniö, P., Elomaa, H., Äijälä, V. K., Karjalainen, H., Tapiainen, V. V., Pohjanen, V.-M., Kemppainen, J., Sliashynskaya, K., Ahtiainen, M., Rintala, J., Meriläinen, S., Rautio, T., Saarnio, J., Mattila, T. T., Lindgren, O., Wirta, E.-V., Helminen, O., Seppälä, T. T., . . . Väyrynen, J. P. (2024). Establishing Criteria for Tumor Necrosis as Prognostic Indicator in Colorectal Cancer. American Journal of Surgical Pathology, 48(10), 1284-1292. https://doi.org/10.1097/PAS.0000000000002286
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Kastinen, Meeri; Sirniö, Päivi; Elomaa, Hanna; Äijälä, Ville K.; Karjalainen, Henna; Tapiainen, Vilja V.; Pohjanen, Vesa-Matti; Kemppainen, Janette; Sliashynskaya, Katja; Ahtiainen, Maarit; et al.
Lehti tai sarja: American Journal of Surgical Pathology
ISSN: 0147-5185
eISSN: 1532-0979
Julkaisuvuosi: 2024
Ilmestymispäivä: 15.07.2024
Volyymi: 48
Lehden numero: 10
Artikkelin sivunumerot: 1284-1292
Kustantaja: Ovid Technologies (Wolters Kluwer Health)
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1097/PAS.0000000000002286
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/96502
Tiivistelmä
Tumor necrosis has been reported to represent an independent prognostic factor in colorectal cancer, but its evaluation methods have not been described in sufficient detail to introduce tumor necrosis evaluation into clinical use. To study the potential of tumor necrosis as a prognostic indicator in colorectal cancer, criteria for 3 methods for its evaluation were defined: the average percentage method (tumor necrosis percentage of the whole tumor), the hotspot method (tumor necrosis percentage in a single hotspot), and the linear method (the diameter of the single largest necrotic focus). Cox regression models were used to calculate cancer-specific mortality hazard ratios (HRs) for tumor necrosis categories in 2 colorectal cancer cohorts with more than 1800 cases. For reproducibility assessment, 30 cases were evaluated by 9 investigators, and Spearman’s rank correlation coefficients and Cohen’s kappa coefficients were calculated. We found that all 3 methods predicted colorectal cancer-specific survival independent of other prognostic parameters, including disease stage, lymphovascular invasion, and tumor budding. The greatest multivariable HRs were observed for the average percentage method (cohort 1: HR for ≥ 40% vs. <3% 3.03, 95% CI, 1.93-4.78; cohort 2: HR for ≥ 40% vs. < 3% 2.97; 95% CI, 1.63-5.40). All 3 methods had high reproducibility, with the linear method showing the highest mean Spearman’s correlation coefficient (0.91) and Cohen’s kappa (0.70). In conclusion, detailed criteria for tumor necrosis evaluation were established. All 3 methods showed good reproducibility and predictive ability. The findings pave the way for the use of tumor necrosis as a prognostic factor in colorectal cancer.
YSO-asiasanat: paksusuolisyöpä; ennusteet; kasvaimet; nekroosi
Liittyvät organisaatiot
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2024
Alustava JUFO-taso: 2
