A1 Journal article (refereed)
Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence (2024)


Healy, D. R., Zarei, I., Mikkonen, S., Soininen, S., Viitasalo, A., Haapala, E. A., Auriola, S., Hanhineva, K., Kolehmainen, M., & Lakka, T. A. (2024). Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence. Communications Biology, 7(1), Article 890. https://doi.org/10.1038/s42003-024-06146-0


JYU authors or editors


Publication details

All authors or editors: Healy, Darren R.; Zarei, Iman; Mikkonen, Santtu; Soininen, Sonja; Viitasalo, Anna; Haapala, Eero A.; Auriola, Seppo; Hanhineva, Kati; Kolehmainen, Marjukka; Lakka, Timo A.

Journal or series: Communications Biology

eISSN: 2399-3642

Publication year: 2024

Publication date: 22/07/2024

Volume: 7

Issue number: 1

Article number: 890

Publisher: Nature Publishing Group

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1038/s42003-024-06146-0

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/96592

Publication is parallel published: https://research.utu.fi/converis/portal/detail/Publication/457303881


Abstract

Environmental and lifestyle factors, including air pollution, impaired diet, and low physical activity, have been associated with cardiometabolic risk factors in childhood and adolescence. However, environmental and lifestyle exposures do not exert their physiological effects in isolation. This study investigated associations between an exposome score to measure the impact of multiple exposures, including diet, physical activity, sleep duration, air pollution, and socioeconomic status, and serum metabolites measured using LC-MS and NMR, compared to the individual components of the score. A general population of 504 children aged 6-9 years at baseline was followed up for eight years. Data were analysed with linear mixed-effects models using the R software. The exposome score was associated with 31 metabolites, of which 12 metabolites were not associated with any individual exposure category. These findings highlight the value of a composite score to predict metabolic changes associated with multiple environmental and lifestyle exposures since childhood.

A composite exposome score was associated with 31 serum metabolites measured by LC-MS and NMR in children followed to adolescence. Altogether, 12 of these associations were unique to the exposome score, with several findings modified by adiposity.


Keywords: children (age groups); young people; cardiovascular diseases; risk factors; environmental factors; metabolic products; serum; lifestyle habits; diets; air pollutants; physical activity; socioeconomic status; longitudinal research


Contributing organizations


Ministry reporting: Yes

VIRTA submission year: 2024

Preliminary JUFO rating: 1


Last updated on 2024-14-09 at 20:06