A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Mitochondrial function is enhanced by thyroid hormones during zebra finch development (2024)
Oefele, M., Hau, M., Ruuskanen, S., & Casagrande, S. (2024). Mitochondrial function is enhanced by thyroid hormones during zebra finch development. Royal Society Open Science, 11, Article 240417. https://doi.org/10.1098/rsos.240417
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Oefele, Marlene; Hau, Michaela; Ruuskanen, Suvi; Casagrande, Stefania
Lehti tai sarja: Royal Society Open Science
eISSN: 2054-5703
Julkaisuvuosi: 2024
Volyymi: 11
Artikkelinumero: 240417
Kustantaja: The Royal Society
Julkaisumaa: Britannia
Julkaisun kieli: englanti
DOI: https://doi.org/10.1098/rsos.240417
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/96650
Tiivistelmä
An organism’s response to its environment is largely determined by changes in the energy supplied by aerobic mitochondrial metabolism via adenosine triphosphate (ATP) production. ATP is especially important under energy-demanding conditions, such as during rapid growth. It is currently poorly understood how environmental factors influence energy metabolism and mitochondrial functioning, but recent studies suggest the role of thyroid hormones (TH). TH are key regulators of growth and metabolism and can be flexibly adjusted to environmental conditions, such as environmental temperature or food availability. To test whether TH enhancement is causally linked to mitochondrial function and growth, we provided TH orally at physiological concentrations during the main growth phase in zebra finch (Taeniopygia guttata) nestlings reared in a challenging environment. TH treatment accelerated maximal mitochondrial working capacity—a trait that reflects mitochondrial ATP production, without affecting growth. To our knowledge, this is the first study to characterize the regulation of mitochondria by TH during development in a semi-naturalistic context and to address implications for fitness-related traits, such as growth.
YSO-asiasanat: aineenvaihdunta; kasvu; mitokondriot; tyreotropiini
Vapaat asiasanat: mitochondria; thyroid hormones; cellularrespiration; growth; metabolism
Liittyvät organisaatiot
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2024
Alustava JUFO-taso: 1
