A1 Journal article (refereed)
Association Between Exercise Systolic Blood Pressure and Risk of Stroke in Men With and Without Cardiovascular Disease (2024)
Jae, S. Y., Gwon, J. G., Kurl, S., Kunutsor, S. K., & Laukkanen, J. A. (2024). Association Between Exercise Systolic Blood Pressure and Risk of Stroke in Men With and Without Cardiovascular Disease. Journal of Cardiopulmonary Rehabilitation and Prevention, 44(5), 377-381. https://doi.org/10.1097/HCR.0000000000000889
JYU authors or editors
Publication details
All authors or editors: Jae, Sae Young; Gwon, Jun Gyo; Kurl, Sudhir; Kunutsor, Setor K.; Laukkanen, Jari A.
Journal or series: Journal of Cardiopulmonary Rehabilitation and Prevention
ISSN: 1932-7501
eISSN: 1932-751X
Publication year: 2024
Publication date: 03/09/2024
Volume: 44
Issue number: 5
Pages range: 377-381
Publisher: Lippincott
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1097/HCR.0000000000000889
Publication open access: Not open
Publication channel open access:
Abstract
We tested the hypothesis that an exaggerated exercise systolic blood pressure (ESBP) would be associated with the risk of stroke in men with and without a history of cardiovascular disease (CVD).
Methods:
An ESBP was defined as a maximal systolic blood pressure (SBP) ≥ 210 mmHg during graded exercise testing on a stationary bike until volitional fatigue in 2410 men aged 42 to 61 yr at baseline.
Results:
Over a median 27-yr follow-up, 419 incident stroke events occurred. In a multivariable adjusted model, men with an ESBP had a significantly increased risk of stroke in the entire cohort (HR = 1.41: 95% CI, 1.15-1.74). This association was still significant following further adjustment for resting SBP (HR = 1.25: 95% CI, 1.01-1.56). In subgroup analysis, ESBP was modestly associated with an increased risk of stroke in men with a history of CVD (HR = 1.37: 95% CI, 0.98-1.93), with no strong evidence of an association in men without a history of CVD (HR = 1.20: 95% CI, 0.90-1.60).
Conclusions:
These findings suggest that the heightened risk of stroke related to ESBP response in a general population-based sample of men may be primarily driven by a history of CVD. The results underscore the importance of considering exercise blood pressure response when interpreting stress tests, particularly in individuals with pre-existing CVD.
Keywords: blood pressure; hypertension; physical stress; myocardial infarction; cardiovascular diseases; men; follow-up study
Contributing organizations
Ministry reporting: Yes
VIRTA submission year: 2024
Preliminary JUFO rating: 1
