A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
The impact of preoperative treatments on the immune environment of rectal cancer (2024)


Wirta, E., Elomaa, H., Ahtiainen, M., Hyöty, M., Seppälä, T. T., Kuopio, T., Böhm, J., Mecklin, J., & Väyrynen, J. P. (2024). The impact of preoperative treatments on the immune environment of rectal cancer. Apmis, 132(12), 1046-1060. https://doi.org/10.1111/apm.13467


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatWirta, Erkki‐Ville; Elomaa, Hanna; Ahtiainen, Maarit; Hyöty, Marja; Seppälä, Toni T.; Kuopio, Teijo; Böhm, Jan; Mecklin, Jukka‐Pekka; Väyrynen, Juha P.

Lehti tai sarjaApmis

ISSN0903-4641

eISSN1600-0463

Julkaisuvuosi2024

Ilmestymispäivä10.09.2024

Volyymi132

Lehden numero12

Artikkelin sivunumerot1046-1060

KustantajaWiley-Blackwell

JulkaisumaaYhdysvallat (USA)

Julkaisun kielienglanti

DOIhttps://doi.org/10.1111/apm.13467

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusOsittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/97056


Tiivistelmä

To improve local disease control, the use of preoperative radiotherapy either alone or combined with chemotherapy has become standard practice in rectal cancer, but it is unclear how these treatments modify the antitumoral immune response. We aimed to evaluate tumor histopathologic features and the prognostic effect of host immune response in rectal cancer with variable treatment modalities. Ninety-five rectal cancers with short-course radiotherapy (SRT), 97 with long-course chemoradiotherapy (CRT), and 154 without preoperative treatments, were evaluated for histopathologic features including Crohn's-like reaction (CLR). CD3+ and CD8+ immunohistochemistry and tumor cells were analyzed from tumor tissue microarray samples to calculate T-cell densities and G-cross function values to estimate cancer cell–T-cell co-localization (proximity score). We found that lymphocyte densities were diminished after SRT, but CLR was scarcer after CRT. Proximity score and CLR density were prognostic for survival in cancer without preoperative treatments and could be combined into an enhanced prognostic score (immune grade). In the irradiated tumors, CLR density remained prognostic while the impact of T-cell infiltration was insufficient alone. In multivariable analysis, the immune grade proved to be an independent prognostic factor for survival. In conclusion, the immune contexture of rectal cancer harbors prognostic significance even after preoperative radiotherapy.


YSO-asiasanatsyöpätauditsädehoitokasvaimetpreoperatiivinen hoito

Vapaat asiasanattumor-infiltrating lymphocytes; Crohn’s-like reaction; short-course radiotherapy; chemo radiotherapy; tumor regression


Liittyvät organisaatiot


OKM-raportointiKyllä

VIRTA-lähetysvuosi2024

Alustava JUFO-taso1


Viimeisin päivitys 2025-11-02 klo 10:58