A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
The impact of preoperative treatments on the immune environment of rectal cancer (2024)
Wirta, E., Elomaa, H., Ahtiainen, M., Hyöty, M., Seppälä, T. T., Kuopio, T., Böhm, J., Mecklin, J., & Väyrynen, J. P. (2024). The impact of preoperative treatments on the immune environment of rectal cancer. Apmis, 132(12), 1046-1060. https://doi.org/10.1111/apm.13467
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Wirta, Erkki‐Ville; Elomaa, Hanna; Ahtiainen, Maarit; Hyöty, Marja; Seppälä, Toni T.; Kuopio, Teijo; Böhm, Jan; Mecklin, Jukka‐Pekka; Väyrynen, Juha P.
Lehti tai sarja: Apmis
ISSN: 0903-4641
eISSN: 1600-0463
Julkaisuvuosi: 2024
Ilmestymispäivä: 10.09.2024
Volyymi: 132
Lehden numero: 12
Artikkelin sivunumerot: 1046-1060
Kustantaja: Wiley-Blackwell
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1111/apm.13467
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/97056
Tiivistelmä
To improve local disease control, the use of preoperative radiotherapy either alone or combined with chemotherapy has become standard practice in rectal cancer, but it is unclear how these treatments modify the antitumoral immune response. We aimed to evaluate tumor histopathologic features and the prognostic effect of host immune response in rectal cancer with variable treatment modalities. Ninety-five rectal cancers with short-course radiotherapy (SRT), 97 with long-course chemoradiotherapy (CRT), and 154 without preoperative treatments, were evaluated for histopathologic features including Crohn's-like reaction (CLR). CD3+ and CD8+ immunohistochemistry and tumor cells were analyzed from tumor tissue microarray samples to calculate T-cell densities and G-cross function values to estimate cancer cell–T-cell co-localization (proximity score). We found that lymphocyte densities were diminished after SRT, but CLR was scarcer after CRT. Proximity score and CLR density were prognostic for survival in cancer without preoperative treatments and could be combined into an enhanced prognostic score (immune grade). In the irradiated tumors, CLR density remained prognostic while the impact of T-cell infiltration was insufficient alone. In multivariable analysis, the immune grade proved to be an independent prognostic factor for survival. In conclusion, the immune contexture of rectal cancer harbors prognostic significance even after preoperative radiotherapy.
YSO-asiasanat: syöpätaudit; sädehoito; kasvaimet; preoperatiivinen hoito
Vapaat asiasanat: tumor-infiltrating lymphocytes; Crohn’s-like reaction; short-course radiotherapy; chemo radiotherapy; tumor regression
Liittyvät organisaatiot
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2024
Alustava JUFO-taso: 1