A2 Katsausartikkeli tieteellisessä aikausilehdessä
Comparison of objectively measured and estimated cardiorespiratory fitness to predict all-cause and cardiovascular disease mortality in adults : A systematic review and meta-analysis of 42 studies representing 35 cohorts and 3.8 million observations (2025)


Singh, B., Cadenas-Sanchez, C., da Costa, B. G., Castro-Piñero, J., Chaput, J.-P., Cuenca-García, M., Maher, C., Marín-Jiménez, N., McGrath, R., Molina-Garcí, P., Myers, J., Gower, B., Ortega, F. B., Lang, J. J., & Tomkinson, G. R. (2025). Comparison of objectively measured and estimated cardiorespiratory fitness to predict all-cause and cardiovascular disease mortality in adults : A systematic review and meta-analysis of 42 studies representing 35 cohorts and 3.8 million observations. Journal of Sport and Health Science, 14, Article 100986. https://doi.org/10.1016/j.jshs.2024.100986


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatSingh, Ben; Cadenas-Sanchez, Cristina; da Costa, Bruno G.G.; Castro-Piñero, José; Chaput, Jean-Philippe; Cuenca-García, Magdalena; Maher, Carol; Marín-Jiménez, Nuria; McGrath, Ryan; Molina-Garcí, Pablo; et al.

Lehti tai sarjaJournal of Sport and Health Science

ISSN2095-2546

eISSN2213-2961

Julkaisuvuosi2025

Ilmestymispäivä11.09.2024

Volyymi14

Artikkelinumero100986

KustantajaElsevier

JulkaisumaaAlankomaat

Julkaisun kielienglanti

DOIhttps://doi.org/10.1016/j.jshs.2024.100986

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusKokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/99975


Tiivistelmä

Background
Cardiorespiratory fitness (CRF) is a powerful health marker recommended by the American Heart Association as a clinical vital sign. Comparing the predictive validity of objectively measured CRF (the “gold standard”) and estimated CRF is clinically relevant because estimated CRF is more feasible. Our objective was to meta-analyze cohort studies to compare the associations of objectively measured, exercise-estimated, and non-exercise-estimated CRF with all-cause and cardiovascular disease (CVD) mortality in adults.

Methods
Systematic searches were conducted in 9 databases (MEDLINE, SPORTDiscus, Embase, Scopus, PsycINFO, Web of Science, PubMed, CINAHL, and the Cochrane Library) up to April 11, 2024. We included full-text refereed cohort studies published in English that quantified the association (using risk estimates with 95% confidence intervals (95%CIs)) of objectively measured, exercise-estimated, and non-exercise-estimated CRF with all-cause and CVD mortality in adults. CRF was expressed as metabolic equivalents (METs) of task. Pooled relative risks (RR) for all-cause and CVD mortality per 1-MET (3.5 mL/kg/min) higher level of CRF were quantified using random-effects models.

Results
Forty-two studies representing 35 cohorts and 3,813,484 observations (81% male) (362,771 all-cause and 56,471 CVD deaths) were included. The pooled RRs for all-cause and CVD mortality per higher MET were 0.86 (95%CI: 0.83–0.88) and 0.84 (95%CI: 0.80–0.87), respectively. For both all-cause and CVD mortality, there were no statistically significant differences in RR per higher MET between objectively measured (RR range: 0.86–0.90) and maximal exercise-estimated (RR range: 0.85–0.86), submaximal exercise-estimated (RR range: 0.91–0.94), and non-exercise-estimated CRF (RR range: 0.81–0.85).

Conclusion
Objectively measured and estimated CRF showed similar dose–response associations for all-cause and CVD mortality in adults. Estimated CRF could provide a practical and robust alternative to objectively measured CRF for assessing mortality risk across diverse populations. Our findings underscore the health-related benefits of higher CRF and advocate for its integration into clinical practice to enhance risk stratification.


YSO-asiasanataikuisetfyysinen kuntoaerobinen suorituskykysydän- ja verisuonitauditkuolleisuusriskinarviointikohorttitutkimus

Vapaat asiasanatadult; cardiorespiratory fitness; cardiovascular diseases; cohort studies; risk assessment.


Liittyvät organisaatiot


OKM-raportointiKyllä

VIRTA-lähetysvuosi2024

Alustava JUFO-taso1


Viimeisin päivitys 2025-05-02 klo 11:55