A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Exercise and brain health in patients with coronary artery disease : study protocol for the HEART-BRAIN randomized controlled trial (2024)
Toval, A., Solis-Urra, P., Bakker, E. A., Sánchez-Aranda, L., Fernández-Ortega, J., Prieto, C., Alonso-Cuenca, R. M., González-García, A., Martín-Fuentes, I., Fernandez-Gamez, B., Olvera-Rojas, M., Coca-Pulido, A., Bellón, D., Sclafani, A., Sanchez-Martinez, J., Rivera-López, R., Herrera-Gómez, N., Peñafiel-Burkhardt, R., López-Espinosa, V., . . . Ortega, F. B. (2024). Exercise and brain health in patients with coronary artery disease : study protocol for the HEART-BRAIN randomized controlled trial. Frontiers in Aging Neuroscience, 16, Article 1437567. https://doi.org/10.3389/fnagi.2024.1437567
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Toval, Angel; Solis-Urra, Patricio; Bakker, Esmée A.; Sánchez-Aranda, Lucía; Fernández-Ortega, Javier; Prieto, Carlos; Alonso-Cuenca, Rosa María; González-García, Alberto; Martín-Fuentes, Isabel; Fernandez-Gamez, Beatriz; et al.
Lehti tai sarja: Frontiers in Aging Neuroscience
eISSN: 1663-4365
Julkaisuvuosi: 2024
Ilmestymispäivä: 23.08.2024
Volyymi: 16
Artikkelinumero: 1437567
Kustantaja: Frontiers Media
Julkaisumaa: Sveitsi
Julkaisun kieli: englanti
DOI: https://doi.org/10.3389/fnagi.2024.1437567
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/97070
Julkaisu on rinnakkaistallennettu: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377337/
Lisätietoja: Study Protocol
Tiivistelmä
Methods: This three-arm, single-blinded RCT will include 90 patients with CAD (50-75 years). Participants will be randomized into: (1) control group-usual care (n = 30), (2) aerobic high-intensity interval training (HIIT) (n = 30), or (3) HIIT combined with resistance exercise training (n = 30). The 12-week intervention includes 3 supervised sessions (45-min each) per week for the exercise groups. Outcomes will be assessed at baseline and post-intervention. The primary outcome is to determine changes in cerebral blood flow assessed by magnetic resonance imaging. Secondary outcomes include changes in brain vascularization, cognitive measures (i.e., general cognition, executive function and episodic memory), and cardiorespiratory fitness. Additional health-related outcomes, and several potential mediators and moderators will be investigated (i.e., brain structure and function, cardiovascular and brain-based biomarkers, hemodynamics, physical function, body composition, mental health, and lifestyle behavior).
Conclusion: The HEART-BRAIN RCT will provide novel insights on how exercise can impact brain health in patients with CAD and the potential mechanisms explaining the heart-brain connection, such as changes in cerebral blood flow. The results may have important clinical implications by increasing the evidence on the effectiveness of exercise-based strategies to delay cognitive decline in this high-risk population.
YSO-asiasanat: sepelvaltimotauti; kuntoliikunta; voimaharjoittelu; kognitio; aivoverenkiertohäiriöt; aivovaltimot; dementia; mielenterveys
Vapaat asiasanat: HIIT; cerebral blood flow; cognition; coronary heart disease; executive function; fitness; ischemic disease; resistance training (RT)
Liittyvät organisaatiot
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2024
Alustava JUFO-taso: 1