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Exercise and brain health in patients with coronary artery disease : study protocol for the HEART-BRAIN randomized controlled trial (2024)


Toval, A., Solis-Urra, P., Bakker, E. A., Sánchez-Aranda, L., Fernández-Ortega, J., Prieto, C., Alonso-Cuenca, R. M., González-García, A., Martín-Fuentes, I., Fernandez-Gamez, B., Olvera-Rojas, M., Coca-Pulido, A., Bellón, D., Sclafani, A., Sanchez-Martinez, J., Rivera-López, R., Herrera-Gómez, N., Peñafiel-Burkhardt, R., López-Espinosa, V., . . . Ortega, F. B. (2024). Exercise and brain health in patients with coronary artery disease : study protocol for the HEART-BRAIN randomized controlled trial. Frontiers in Aging Neuroscience, 16, Article 1437567. https://doi.org/10.3389/fnagi.2024.1437567


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatToval, Angel; Solis-Urra, Patricio; Bakker, Esmée A.; Sánchez-Aranda, Lucía; Fernández-Ortega, Javier; Prieto, Carlos; Alonso-Cuenca, Rosa María; González-García, Alberto; Martín-Fuentes, Isabel; Fernandez-Gamez, Beatriz; et al.

Lehti tai sarjaFrontiers in Aging Neuroscience

eISSN1663-4365

Julkaisuvuosi2024

Ilmestymispäivä23.08.2024

Volyymi16

Artikkelinumero1437567

KustantajaFrontiers Media

JulkaisumaaSveitsi

Julkaisun kielienglanti

DOIhttps://doi.org/10.3389/fnagi.2024.1437567

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusKokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/97070

Julkaisu on rinnakkaistallennettuhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377337/

LisätietojaStudy Protocol


Tiivistelmä

Introduction: Patients with coronary artery disease (CAD) have a higher risk of developing cognitive impairment and mental health disorders compared to the general population. Physical exercise might improve their brain health. The overall goal of the HEART-BRAIN randomized controlled trial (RCT) is to investigate the effects of different types of exercise on brain health outcomes in patients with CAD, and the underlying mechanisms.

Methods: This three-arm, single-blinded RCT will include 90 patients with CAD (50-75 years). Participants will be randomized into: (1) control group-usual care (n = 30), (2) aerobic high-intensity interval training (HIIT) (n = 30), or (3) HIIT combined with resistance exercise training (n = 30). The 12-week intervention includes 3 supervised sessions (45-min each) per week for the exercise groups. Outcomes will be assessed at baseline and post-intervention. The primary outcome is to determine changes in cerebral blood flow assessed by magnetic resonance imaging. Secondary outcomes include changes in brain vascularization, cognitive measures (i.e., general cognition, executive function and episodic memory), and cardiorespiratory fitness. Additional health-related outcomes, and several potential mediators and moderators will be investigated (i.e., brain structure and function, cardiovascular and brain-based biomarkers, hemodynamics, physical function, body composition, mental health, and lifestyle behavior).

Conclusion: The HEART-BRAIN RCT will provide novel insights on how exercise can impact brain health in patients with CAD and the potential mechanisms explaining the heart-brain connection, such as changes in cerebral blood flow. The results may have important clinical implications by increasing the evidence on the effectiveness of exercise-based strategies to delay cognitive decline in this high-risk population.


YSO-asiasanatsepelvaltimotautikuntoliikuntavoimaharjoittelukognitioaivoverenkiertohäiriötaivovaltimotdementiamielenterveys

Vapaat asiasanatHIIT; cerebral blood flow; cognition; coronary heart disease; executive function; fitness; ischemic disease; resistance training (RT)


Liittyvät organisaatiot


OKM-raportointiKyllä

VIRTA-lähetysvuosi2024

Alustava JUFO-taso1


Viimeisin päivitys 2024-19-10 klo 20:06