A2 Katsausartikkeli tieteellisessä aikausilehdessä
Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections (2024)

Faizan, B. M., Srdanović, S., Sundberg, L.-R., Kristín, E. H., Marjomäki, V., & Dekker, F. J. (2024). Impact of HDAC inhibitors on macrophage polarization to enhance innate immunity against infections. Drug Discovery Today, 29(11), Article 104193. https://doi.org/10.1016/j.drudis.2024.104193

JYU-tekijät tai -toimittajat

Sundberg, Lotta-Riina
Marjomäki, Varpu

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Faizan, Bhat Mohammad; Srdanović, Sonja; Sundberg, Lotta-Riina; Kristín, Einarsdóttir Helga; Marjomäki, Varpu; Dekker, Frank J.

Lehti tai sarja: Drug Discovery Today

ISSN: 1359-6446

eISSN: 1878-5832

Julkaisuvuosi: 2024

Ilmestymispäivä: 26.09.2024

Volyymi: 29

Lehden numero: 11

Artikkelinumero: 104193

Kustantaja: Elsevier

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1016/j.drudis.2024.104193

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/97613

Tiivistelmä

Innate immunity plays an important role in host defense against pathogenic infections. It involves macrophage polarization into either the pro-inflammatory M1 or the anti-inflammatory M2 phenotype, influencing immune stimulation or suppression, respectively. Epigenetic changes during immune reactions contribute to long-term innate immunity imprinting on macrophage polarization. It is becoming increasingly evident that epigenetic modulators, such as histone deacetylase (HDAC) inhibitors (HDACi), enable the enhancement of innate immunity by tailoring macrophage polarization in response to immune stressors. In this review, we summarize current literature on the impact of HDACi and other epigenetic modulators on the functioning of macrophages during diseases that have a strong immune component, such as infections. Depending on the disease context and the chosen therapeutic intervention, HDAC1, HDAC2, HDAC3, HDAC6, or HDAC8 are particularly important in influencing macrophage polarization towards either M1 or M2 phenotypes. We anticipate that therapeutic strategies based on HDAC epigenetic mechanisms will provide a unique approach to boost immunity against disease challenges, including resistant infections.

YSO-asiasanat: infektiot; makrofagit; tulehdus; immuunivaste; immuunijärjestelmä; epigenetiikka; antibioottiresistenssi