A1 Journal article (refereed)
Isolation and characterization of Yersinia phage fMtkYen3-01 (2024)

Goladze, S., Patpatia, S., Tuomala, H., Ylänne, M., Gachechiladze, N., de Oliveira Patricio, D., Skurnik, M., & Sundberg, L.-R. (2024). Isolation and characterization of Yersinia phage fMtkYen3-01. Archives of Virology, 169, Article 226. https://doi.org/10.1007/s00705-024-06149-6

JYU authors or editors

Publication details

All authors or editors: Goladze, Sophia; Patpatia, Sheetal; Tuomala, Henni; Ylänne, Matti; Gachechiladze, Nino; de Oliveira Patricio, Daniel; Skurnik, Mikael; Sundberg, Lotta-Riina

Journal or series: Archives of Virology

ISSN: 0304-8608

eISSN: 1432-8798

Publication year: 2024

Publication date: 19/10/2024

Volume: 169

Article number: 226

Publisher: Springer Nature

Publication language: English

DOI: https://doi.org/10.1007/s00705-024-06149-6

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/97555

Abstract

Yersinia enterocolitica causes yersiniosis, the third most common gastrointestinal infection in humans throughout Europe. The emergence of multidrug resistance and the lack of effective new antibiotics have drawn attention to phage therapy as a treatment option. Here, we report the complete genome sequence of phage fMtkYen3-01, which infects Y. enterocolitica serotype O:3 strains. This phage has a genome 40,415 bp in length with 45.1% GC content and 49 predicted genes. fMtkYen3-01 infected 9.5% of the 42 Y. enterocolitica strains tested and showed stability at 25–40 °C, as well as pH 5.0–10.0. These results suggest the therapeutic potential of this phage.

Keywords: Yersinia bacteria; infections; antibiotic resistance; bacteriophages; phage therapy; genomics; sequencing

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Ministry reporting: Yes

VIRTA submission year: 2024

Preliminary JUFO rating: 1