A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Androgen-mediated maternal effects and trade-offs : postnatal hormone development, growth, and survivorship in wild meerkats (2024)


Davies, C. S., Shearer, C. L., Greene, L. K., Mitchell, J., Walsh, D., Goerlich, V. C., Clutton-Brock Tim, H., & Drea, C. M. (2024). Androgen-mediated maternal effects and trade-offs : postnatal hormone development, growth, and survivorship in wild meerkats. Frontiers in Endocrinology, 15, Article 1418056. https://doi.org/10.3389/fendo.2024.1418056


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatDavies, Charli S.; Shearer, Caroline L.; Greene, Lydia K.; Mitchell, Jessica; Walsh, Debbie; Goerlich, Vivian C.; Clutton-Brock Tim, H.; Drea, Christine M.

Lehti tai sarjaFrontiers in Endocrinology

eISSN1664-2392

Julkaisuvuosi2024

Ilmestymispäivä30.09.2024

Volyymi15

Artikkelinumero1418056

KustantajaFrontiers Media

Julkaisun kielienglanti

DOIhttps://doi.org/10.3389/fendo.2024.1418056

Linkki tutkimusaineistoonhttps://github.com/cls83211/davies-sheareretal2024

Julkaisun avoin saatavuusAvoimesti saatavilla

Julkaisukanavan avoin saatavuusKokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/97729

Julkaisu on rinnakkaistallennettuhttps://hdl.handle.net/10161/31557


Tiivistelmä

Introduction: Mammalian reproductive and somatic development is regulated by steroid hormones, growth hormone (GH), and insulin-like growth factor-1 (IGF-1). Based largely on information from humans, model organisms, and domesticated animals, testosterone (T) and the GH/IGF-1 system activate sexually differentiated development, promoting male-biased growth, often at a cost to health and survivorship. To test if augmented prenatal androgen exposure in females produces similar developmental patterns and trade-offs, we examine maternal effects in wild meerkats (Suricata suricatta), a non-model species in which adult females naturally, albeit differentially by status, express exceptionally high androgen concentrations, particularly during pregnancy. In this cooperative breeder, the early growth of daughters predicts future breeding status and reproductive success.

Methods: We examine effects of normative and experimentally induced variation in maternal androgens on the ontogenetic patterns in offspring reproductive hormones (androstenedione, A4; T; estradiol, E2), IGF-1, growth from pup emergence at 1 month to puberty at 1 year, and survivorship. Specifically, we compare the male and female offspring of dominant control (DC or high-T), subordinate control (SC or lower-T), and dominant treated (DT or blocked-T) dams, the latter having experienced antiandrogen treatment in late gestation.

Results: Meerkat offspring showed sex differences in absolute T and IGF-1 concentrations, developmental rates of A4 and E2 expression, and survivorship — effects that were sometimes socially or environmentally modulated. Atypical for mammals were the early male bias in T that disappeared by puberty, the absence of sex differences in A4 and E2, and the female bias in IGF-1. Food availability was linked to steroid concentrations in females and to IGF-1, potentially growth, and survival in both sexes. Maternal treatment significantly affected rates of T, E2, and IGF-1 expression, and weight, with marginal effects on survivorship; offspring of DT dams showed peak IGF-1 concentrations and the best survivorship.

Discussion: Maternal effects thus impact offspring development in meerkats, with associated trade-offs: Whereas prenatal androgens modify postnatal reproductive and somatic physiology, benefits associated with enhanced competitiveness in DC lineages may have initial costs of reduced IGF-1, delay in weight gain, and decreased survivorship. These novel data further confirm the different evolutionary and mechanistic pathways to cooperative breeding and call for greater consideration of natural endocrine variation in both sexes.


YSO-asiasanatsukupuolierotsukupuolihormonitandrogeenitalkionkehityshormonaaliset tekijäthormonaaliset vaikutuksetendokrinologia

Vapaat asiasanatfemale masculinization; flutamide; IGF-1; life-history trade-offs; ontogeny; prenatal programming; sex steroids; sexual differentiation; Suricata suricatta


Liittyvät organisaatiot


OKM-raportointiKyllä

VIRTA-lähetysvuosi2024

Alustava JUFO-taso1


Viimeisin päivitys 2024-16-11 klo 20:05