A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Androgen-mediated maternal effects and trade-offs : postnatal hormone development, growth, and survivorship in wild meerkats (2024)
Davies, C. S., Shearer, C. L., Greene, L. K., Mitchell, J., Walsh, D., Goerlich, V. C., Clutton-Brock Tim, H., & Drea, C. M. (2024). Androgen-mediated maternal effects and trade-offs : postnatal hormone development, growth, and survivorship in wild meerkats. Frontiers in Endocrinology, 15, Article 1418056. https://doi.org/10.3389/fendo.2024.1418056
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Davies, Charli S.; Shearer, Caroline L.; Greene, Lydia K.; Mitchell, Jessica; Walsh, Debbie; Goerlich, Vivian C.; Clutton-Brock Tim, H.; Drea, Christine M.
Lehti tai sarja: Frontiers in Endocrinology
eISSN: 1664-2392
Julkaisuvuosi: 2024
Ilmestymispäivä: 30.09.2024
Volyymi: 15
Artikkelinumero: 1418056
Kustantaja: Frontiers Media
Julkaisun kieli: englanti
DOI: https://doi.org/10.3389/fendo.2024.1418056
Linkki tutkimusaineistoon: https://github.com/cls83211/davies-sheareretal2024
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/97729
Julkaisu on rinnakkaistallennettu: https://hdl.handle.net/10161/31557
Tiivistelmä
Methods: We examine effects of normative and experimentally induced variation in maternal androgens on the ontogenetic patterns in offspring reproductive hormones (androstenedione, A4; T; estradiol, E2), IGF-1, growth from pup emergence at 1 month to puberty at 1 year, and survivorship. Specifically, we compare the male and female offspring of dominant control (DC or high-T), subordinate control (SC or lower-T), and dominant treated (DT or blocked-T) dams, the latter having experienced antiandrogen treatment in late gestation.
Results: Meerkat offspring showed sex differences in absolute T and IGF-1 concentrations, developmental rates of A4 and E2 expression, and survivorship — effects that were sometimes socially or environmentally modulated. Atypical for mammals were the early male bias in T that disappeared by puberty, the absence of sex differences in A4 and E2, and the female bias in IGF-1. Food availability was linked to steroid concentrations in females and to IGF-1, potentially growth, and survival in both sexes. Maternal treatment significantly affected rates of T, E2, and IGF-1 expression, and weight, with marginal effects on survivorship; offspring of DT dams showed peak IGF-1 concentrations and the best survivorship.
Discussion: Maternal effects thus impact offspring development in meerkats, with associated trade-offs: Whereas prenatal androgens modify postnatal reproductive and somatic physiology, benefits associated with enhanced competitiveness in DC lineages may have initial costs of reduced IGF-1, delay in weight gain, and decreased survivorship. These novel data further confirm the different evolutionary and mechanistic pathways to cooperative breeding and call for greater consideration of natural endocrine variation in both sexes.
YSO-asiasanat: sukupuolierot; sukupuolihormonit; androgeenit; alkionkehitys; hormonaaliset tekijät; hormonaaliset vaikutukset; endokrinologia
Vapaat asiasanat: female masculinization; flutamide; IGF-1; life-history trade-offs; ontogeny; prenatal programming; sex steroids; sexual differentiation; Suricata suricatta
Liittyvät organisaatiot
OKM-raportointi: Kyllä
VIRTA-lähetysvuosi: 2024
Alustava JUFO-taso: 1