A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
A New Bromo-Mn(II) Complex with 1,3,5-Triazine Derivative: Synthesis, Crystal Structure, DFT and Biological Studies (2024)

Khattab Sara, M., Altowyan Mezna Saleh, El-Faham Ayman, Barakat Assem, Haukka Matti, Abu-Youssef Morsy A., M., Soliman Saied, M. (2024). A New Bromo-Mn(II) Complex with 1,3,5-Triazine Derivative: Synthesis, Crystal Structure, DFT and Biological Studies. Inorganics, 12, 284. https://doi.org/10.3390/inorganics12110284

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Khattab, Sara, M.; Altowyan, Mezna Saleh; El-Faham, Ayman; Barakat, Assem; Haukka, Matti; Abu-Youssef, Morsy A. M.; Soliman, Saied M.

Lehti tai sarja: Inorganics

eISSN: 2304-6740

Julkaisuvuosi: 2024

Ilmestymispäivä: 31.10.2024

Volyymi: 12

Lehden numero: 11

Artikkelinumero: 284

Kustantaja: MDPI AG

Julkaisumaa: Sveitsi

Julkaisun kieli: englanti

DOI: https://doi.org/10.3390/inorganics12110284

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/98147

Tiivistelmä

The crystal structure and topology analyses of a new bromo-Mn(II) complex with 2,4-bis(3,5dimethyl-1H-pyrazol-1-yl)-6-methoxy-1,3,5-triazine (MBPT) were reported. Its structure was confirmed using single-crystal X-ray diffraction to create the formula [Mn(MBPT)Br(H2O)2]ClO4. Its crystal system was monoclinic and its space group was p21. The Mn(II) was coordinated with MBPT as a NNN-pincer ligand, with one bromide ion in the equatorial plane. The two axial terminals were occupied by two trans water molecules. H…H, N…H, Br…H, C…H and O…H were the predominant intermolecular contacts, while Br…H, O…H and C…O were the significant contacts based on Hirshfeld analysis. Moreover, anion–ᴨ interaction was found between C(s-triazine) and O(perchlorate). This complex had better antioxidant activity than the free ligand (MBPT). In addition, the cytotoxicity of the [Mn(MBPT)Br(H2O)2]ClO4 complex showed better results against HepG-2 and MCF-7 cells, recording IC50 values of 31.11 ± 2.04 and 50.05 ± 2.16 µM, respectively, compared to the free ligand (IC50 = 671.44 ± 21.41 and 1113.55 ± 29.77 µM). In comparison to cis-platin as a reference drug, the IC50 values were 63 and 80 μM, respectively, which indicated the promising anticancer activity of the studied compound against both cell lines. In terms of the safety of normal cells, the Mn(II) complex recorded a high IC50 value of 359.10 ± 8.72 µM against the WI-38 non-cancerous cell line. The complex showed better activity towards Staphylococcus aureus, Bacillus subtilis, and Proteus vulgaris relative to the free MBPT, but had low to moderate activity compared to Gentamycin as an antibacterial positive control.

YSO-asiasanat: kemiallinen synteesi; kompleksiyhdisteet; röntgenkristallografia

Vapaat asiasanat:  X-ray crystal structure; bis-pyrazol-s-triazine; pincer Mn(II) complex; Hirshfeld; biological studies

Liittyvät organisaatiot

OKM-raportointi: Kyllä

VIRTA-lähetysvuosi: 2024

Alustava JUFO-taso: 1