A1 Journal article (refereed)
Trait self-compassion enhances activation in the medial prefrontal cortex during fear extinction : An fNIRS study (2024)

Chen, T., Mei, Y., Zhou, S., Dou, H., & Lei, Y. (2024). Trait self-compassion enhances activation in the medial prefrontal cortex during fear extinction : An fNIRS study. International Journal of Clinical and Health Psychology, 24(4), Article 100516. https://doi.org/10.1016/j.ijchp.2024.100516

JYU authors or editors

Publication details

All authors or editors: Chen, Tingyuan; Mei, Ying; Zhou, Siyuan; Dou, Haoran; Lei, Yi

Journal or series: International Journal of Clinical and Health Psychology

ISSN: 1697-2600

eISSN: 2174-0852

Publication year: 2024

Publication date: 06/11/2024

Volume: 24

Issue number: 4

Article number: 100516

Publisher: Elsevier

Publication country: Spain

Publication language: English

DOI: https://doi.org/10.1016/j.ijchp.2024.100516

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/98315

Abstract

Fear acquisition and fear extinction are the most widely used experimental models to study anxiety related disorders, with the medial prefrontal cortex (mPFC) playing an important role in this process. Previous research suggests that trait self-compassion is associated with lower anxiety, but the neural mechanisms underlying this relationship remain unclear. Women generally exhibit lower self-compassion than men, making them more vulnerable to fear and anxiety. In this study, female participants were divided into two groups - high and low trait self-compassion, based on their scores on the Self-Compassion Scale-Short Form (SCS-SF). Both groups completed fear acquisition and fear extinction tasks, during which conditioned responses (CRs) were measured using self-reported unconditioned stimulus (US) expectancy ratings, skin conductance response (SCR), and functional near-infrared spectroscopy (fNIRS). The results showed that in the fear acquisition phase, all participants successfully acquired fear, showing greater responses to threat stimuli than safety stimuli. However, participants with high trait self-compassion exhibited lower SCR than those with low trait self-compassion. In the fear extinction phase, compared to individuals with low trait self-compassion, individuals with high trait self-compassion exhibited more effective fear extinction learning, characterized by lower US expectancy ratings, lower SCR, and higher mPFC activation. Moreover, trait self-compassion was significantly correlated with the behavioral extinction ability and the mPFC activation during the late phase of fear extinction, and behavioral extinction ability was significantly correlated with mPFC activation. The findings of this study suggest individuals with high trait self-compassion have better physiological flexibility during fear acquisition and fear extinction, and may through enhancing mPFC activation to facilitate fear extinction. The results provide new insights into the pathological mechanisms of anxiety.

Keywords: fear (emotions); fears (specific); self-acceptance; acceptance (psychology); near infrared spectroscopy; anxiety disorders; neuropsychology

Free keywords: trait self-compassion; fear acquisition; fear extinction; fNIRS; medial prefrontal cortex

Contributing organizations

Ministry reporting: Yes

VIRTA submission year: 2024

Preliminary JUFO rating: 1