A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Phase matters: responding to and learning about peripheral stimuli depends on hippocampal θ phase at stimulus onset (2015)
Nokia, M., Waselius, T., Mikkonen, J., Wikgren, J., & Penttonen, M. (2015). Phase matters: responding to and learning about peripheral stimuli depends on hippocampal θ phase at stimulus onset. Learning and Memory, 22(6), 307-317. https://doi.org/10.1101/lm.038166.115
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Nokia, Miriam; Waselius, Tomi; Mikkonen, Jarno; Wikgren, Jan; Penttonen, Markku
Lehti tai sarja: Learning and Memory
ISSN: 1072-0502
eISSN: 1549-5485
Julkaisuvuosi: 2015
Volyymi: 22
Lehden numero: 6
Artikkelin sivunumerot: 307-317
Kustantaja: Cold Spring Harbor Laboratory Press
Julkaisumaa: Yhdysvallat (USA)
Julkaisun kieli: englanti
DOI: https://doi.org/10.1101/lm.038166.115
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/45973
Tiivistelmä
Hippocampal θ (3–12 Hz) oscillations are implicated in learning and memory, but their functional role remains unclear. We studied the effect of the phase of local θ oscillation on hippocampal responses to a neutral conditioned stimulus (CS) and subsequent learning of classical trace eyeblink conditioning in adult rabbits. High-amplitude, regular hippocampal θ-band responses (that predict good learning) were elicited by the CS when it was timed to commence at the fissure θ trough (Trough group). Regardless, learning in this group was not enhanced compared with a yoked control group, possibly due to a ceiling effect. However, when the CS was consistently presented to the peak of θ (Peak group), hippocampal θ-band responding was less organized and learning was retarded. In well-trained animals, the hippocampal θ phase at CS onset no longer affected performance of the learned response, suggesting a time-limited role for hippocampal processing in learning. To our knowledge, this is the first study to demonstrate that timing a peripheral stimulus to a specific phase of the hippocampal θ cycle produces robust effects on the synchronization of neural responses and affects learning at the behavioral level. Our results support the notion that the phase of spontaneous hippocampal θ oscillation is a means of regulating the processing of information in the brain to a behaviorally relevant degree.
YSO-asiasanat: oppiminen
Vapaat asiasanat: memory; hippocampal
Liittyvät organisaatiot
Hankkeet, joissa julkaisu on tehty
- Hippokampuksen värähtelyt ja assosiatiivinen oppiminen: Ulos sokkelosta ja tutkimaan uusia aaltoja
- Nokia, Miriam
- Suomen Akatemia
OKM-raportointi: Kyllä
Raportointivuosi: 2015
JUFO-taso: 2