A1 Journal article (refereed)
Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei (2016)


Abdissa, N., Pan, F., Gruhonjic, A., Gräfenstein, J., Fitzpatrick, P. A., Landberg, G., Rissanen, K., Yenesew, A., & Erdélyi, M. (2016). Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei. Journal of Natural Products, 79(9), 2181-2187. https://doi.org/10.1021/acs.jnatprod.6b00178


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Publication details

All authors or editors: Abdissa, Negera; Pan, Fangfang; Gruhonjic, Amra; Gräfenstein, Jürgen; Fitzpatrick, Paul A.; Landberg, Göran; Rissanen, Kari; Yenesew, Abiy; Erdélyi, Máté

Journal or series: Journal of Natural Products

ISSN: 0163-3864

eISSN: 1520-6025

Publication year: 2016

Volume: 79

Issue number: 9

Pages range: 2181-2187

Publisher: ACS Publications; The American Society of Pharmacognosy

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1021/acs.jnatprod.6b00178

Publication open access: Not open

Publication channel open access:


Abstract

The phytochemical investigation of the CH2Cl2/MeOH (1:1) extract of the roots of Pentas parvifolia led to the isolation of three new naphthalenes, parvinaphthols A (1), B (2), and C (3), two known anthraquinones, and five known naphthalene derivatives. Similar investigation of the roots of Pentas bussei afforded a new polycyclic naphthalene, busseihydroquinone E (4), a new 2,2′-binaphthralenyl-1,1′-dione, busseihydroquinone F (5), and five known naphthalenes. All purified metabolites were characterized by NMR and MS data analyses, whereas the absolute configurations of 3 and 4 were determined by single-crystal X-ray diffraction studies. The E-geometry of compound 5 was supported by DFT-based chemical shift calculations. Compounds 2–4 showed marginal cytotoxicity against the MDA-MB-231 human triple-negative breast cancer cell line with IC50 values ranging from 62.3 to 129.6 μM.


Keywords: plants; bioactive compounds; aromatic hydrocarbons

Free keywords: phytochemicals; naphthalenes; naphthalene derivatives; Pentas


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Ministry reporting: Yes

Reporting Year: 2016

JUFO rating: 1


Last updated on 2021-18-06 at 18:51