A1 Journal article (refereed)
Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei (2016)


Abdissa, Negera; Pan, Fangfang; Gruhonjic, Amra; Gräfenstein, Jürgen; Fitzpatrick, Paul A.; Landberg, Göran; Rissanen, Kari; Yenesew, Abiy; Erdélyi, Máté (2016). Naphthalene Derivatives from the Roots of Pentas parvifolia and Pentas bussei. Journal of Natural Products, 79 (9), 2181-2187. DOI: 10.1021/acs.jnatprod.6b00178


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Publication details

All authors or editors: Abdissa, Negera; Pan, Fangfang; Gruhonjic, Amra; Gräfenstein, Jürgen; Fitzpatrick, Paul A.; Landberg, Göran; Rissanen, Kari; Yenesew, Abiy; Erdélyi, Máté

Journal or series: Journal of Natural Products

ISSN: 0163-3864

eISSN: 1520-6025

Publication year: 2016

Volume: 79

Issue number: 9

Pages range: 2181-2187

Publisher: ACS Publications; The American Society of Pharmacognosy

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1021/acs.jnatprod.6b00178

Open Access: Publication channel is not openly available


Abstract

The phytochemical investigation of the CH2Cl2/MeOH (1:1) extract of the roots of Pentas parvifolia led to the isolation of three new naphthalenes, parvinaphthols A (1), B (2), and C (3), two known anthraquinones, and five known naphthalene derivatives. Similar investigation of the roots of Pentas bussei afforded a new polycyclic naphthalene, busseihydroquinone E (4), a new 2,2′-binaphthralenyl-1,1′-dione, busseihydroquinone F (5), and five known naphthalenes. All purified metabolites were characterized by NMR and MS data analyses, whereas the absolute configurations of 3 and 4 were determined by single-crystal X-ray diffraction studies. The E-geometry of compound 5 was supported by DFT-based chemical shift calculations. Compounds 2–4 showed marginal cytotoxicity against the MDA-MB-231 human triple-negative breast cancer cell line with IC50 values ranging from 62.3 to 129.6 μM.


Keywords: plants; bioactive compounds; aromatic hydrocarbons

Free keywords: phytochemicals; naphthalenes; naphthalene derivatives; Pentas


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Ministry reporting: Yes

Reporting Year: 2016

JUFO rating: 1


Last updated on 2021-03-03 at 18:56