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Evidence for the mechanosensor function of filamin in tissue development (2016)

Huelsmann, S., Rintanen, N., Sethi, R., Brown, N. H., & Ylänne, J. (2016). Evidence for the mechanosensor function of filamin in tissue development. Scientific Reports, 6, Article 32798. https://doi.org/10.1038/srep32798

JYU-tekijät tai -toimittajat

Huelsmann, Sven
Rintanen, Nina
Sethi, Ritika
Ylänne, Jari

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Huelsmann, Sven; Rintanen, Nina; Sethi, Ritika; Brown, Nicholas H.; Ylänne, Jari

Lehti tai sarja: Scientific Reports

ISSN: 2045-2322

eISSN: 2045-2322

Julkaisuvuosi: 2016

Volyymi: 6

Lehden numero: 0

Artikkelinumero: 32798

Kustantaja: Nature Publishing Group

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1038/srep32798

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/51309

Tiivistelmä

Cells integrate mechanical properties of their surroundings to form multicellular, three-dimensional tissues of appropriate size and spatial organisation. Actin cytoskeleton-linked proteins such as talin, vinculin and filamin function as mechanosensors in cells, but it has yet to be tested whether the mechanosensitivity is important for their function in intact tissues. Here we tested, how filamin mechanosensing contributes to oogenesis in Drosophila. Mutations that require more or less force to open the mechanosensor region demonstrate that filamin mechanosensitivity is important for the maturation of actin-rich ring canals that are essential for Drosophila egg development. The open mutant was more tightly bound to the ring canal structure while the closed mutant dissociated more frequently. Thus, our results show that an appropriate level of mechanical sensitivity is required for filamins’ function and dynamics during Drosophila egg growth and support the structure-based model in which the opening and closing of the mechanosensor region regulates filamin binding to cellular components.

Vapaat asiasanat: mechanosensor function; tissue development

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