A1 Journal article (refereed)
Flavonoids from Erythrina schliebenii (2017)
Nyandoro, S. S., Munissi, J. J. E., Kombo, M., Mgina, C. A., Pan, F., Gruhonjic, A., Fitzpatrick, P., Lu, Y., Wang, B., Rissanen, K., & Erdélyi, M. (2017). Flavonoids from Erythrina schliebenii. Journal of Natural Products, 80(2), 377-383. https://doi.org/10.1021/acs.jnatprod.6b00839
JYU authors or editors
Publication details
All authors or editors: Nyandoro, Stephen S.; Munissi, Joan J. E.; Kombo, Msim; Mgina, Clarence A.; Pan, Fangfang; Gruhonjic, Amra; Fitzpatrick, Paul; Lu, Yu; Wang, Bin; Rissanen, Kari; et al.
Journal or series: Journal of Natural Products
ISSN: 0163-3864
eISSN: 1520-6025
Publication year: 2017
Volume: 80
Issue number: 2
Pages range: 377-383
Publisher: American Chemical Society; American Society of Pharmacognosy
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1021/acs.jnatprod.6b00839
Publication open access: Not open
Publication channel open access:
Abstract
Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2–4), and nineteen known natural products (5–23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32–64 μg mL–1 and 36.9–101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50 values of 13.0–290.6 μM (pure compounds) and 38.3 to >100 μg mL–1 (crude extracts).
Keywords: flavonoids
Free keywords: Erythrina schliebenii
Contributing organizations
Related projects
- Weak Interactions as Structural Elements in Self-assembling Molecular Systems
- Rissanen, Kari
- Research Council of Finland
- Weak Interactions as Structural Elements in Self-assembling Molecular Systems (research costs)
- Rissanen, Kari
- Research Council of Finland
Ministry reporting: Yes
Reporting Year: 2017
JUFO rating: 1