A1 Journal article (refereed)
Flavonoids from Erythrina schliebenii (2017)


Nyandoro, S. S., Munissi, J. J. E., Kombo, M., Mgina, C. A., Pan, F., Gruhonjic, A., Fitzpatrick, P., Lu, Y., Wang, B., Rissanen, K., & Erdélyi, M. (2017). Flavonoids from Erythrina schliebenii. Journal of Natural Products, 80(2), 377-383. https://doi.org/10.1021/acs.jnatprod.6b00839


JYU authors or editors


Publication details

All authors or editorsNyandoro, Stephen S.; Munissi, Joan J. E.; Kombo, Msim; Mgina, Clarence A.; Pan, Fangfang; Gruhonjic, Amra; Fitzpatrick, Paul; Lu, Yu; Wang, Bin; Rissanen, Kari; et al.

Journal or seriesJournal of Natural Products

ISSN0163-3864

eISSN1520-6025

Publication year2017

Volume80

Issue number2

Pages range377-383

PublisherAmerican Chemical Society; American Society of Pharmacognosy

Publication countryUnited States

Publication languageEnglish

DOIhttps://doi.org/10.1021/acs.jnatprod.6b00839

Publication open accessNot open

Publication channel open access


Abstract

Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2–4), and nineteen known natural products (5–23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32–64 μg mL–1 and 36.9–101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50 values of 13.0–290.6 μM (pure compounds) and 38.3 to >100 μg mL–1 (crude extracts).


Keywordsflavonoids

Free keywordsErythrina schliebenii


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Related projects


Ministry reportingYes

Reporting Year2017

JUFO rating1


Last updated on 2023-18-12 at 13:00