A1 Journal article (refereed)
Flavonoids from Erythrina schliebenii (2017)


Nyandoro, S. S., Munissi, J. J. E., Kombo, M., Mgina, C. A., Pan, F., Gruhonjic, A., . . . Erdélyi, M. (2017). Flavonoids from Erythrina schliebenii. Journal of Natural Products, 80 (2), 377-383. doi:10.1021/acs.jnatprod.6b00839


JYU authors or editors


Publication details

All authors or editors: Nyandoro, Stephen S.; Munissi, Joan J. E.; Kombo, Msim; Mgina, Clarence A.; Pan, Fangfang; Gruhonjic, Amra; Fitzpatrick, Paul; Lu, Yu; Wang, Bin; Rissanen, Kari; et al.

Journal or series: Journal of Natural Products

ISSN: 0163-3864

eISSN: 1520-6025

Publication year: 2017

Volume: 80

Issue number: 2

Pages range: 377-383

Publisher: American Chemical Society; American Society of Pharmacognosy

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1021/acs.jnatprod.6b00839

Open Access: Publication channel is not openly available


Abstract

Prenylated and O-methylflavonoids including one new pterocarpan (1), three new isoflavones (2–4), and nineteen known natural products (5–23) were isolated and identified from the root, stem bark, and leaf extracts of Erythrina schliebenii. The crude extracts and their constituents were evaluated for antitubercular activity against Mycobacterium tuberculosis (H37Rv strain), showing MICs of 32–64 μg mL–1 and 36.9–101.8 μM, respectively. Evaluation of their toxicity against the aggressive human breast cancer cell line MDA-MB-231 indicated EC50 values of 13.0–290.6 μM (pure compounds) and 38.3 to >100 μg mL–1 (crude extracts).


Keywords: flavonoids

Free keywords: Erythrina schliebenii


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Ministry reporting: Yes

Reporting Year: 2017

JUFO rating: 1


Last updated on 2020-17-10 at 21:46