A1 Journal article (refereed)
2H-[1,3]Oxazino[3,2-α]indolin-4(3H)-ones : A Class Of Polyheterocyclic Indole-Based Compounds (2018)

Hartmann, J. M., Groot, M. D., Schäringer, K., Henke, K., Rissanen, K., & Albrec, M. (2018). 2H-[1,3]Oxazino[3,2-α]indolin-4(3H)-ones : A Class Of Polyheterocyclic Indole-Based Compounds. European Journal of Organic Chemistry, 2018(7), 901-907. https://doi.org/10.1002/ejoc.201701630

JYU authors or editors

Publication details

All authors or editors: Hartmann, Jan M.; Groot, Marita de; Schäringer, Katja; Henke, Kira; Rissanen, Kari; Albrec, Markus

Journal or series: European Journal of Organic Chemistry

ISSN: 1434-193X

eISSN: 1099-0690

Publication year: 2018

Volume: 2018

Issue number: 7

Pages range: 901-907

Publisher: Wiley-VCH

Publication country: Germany

Publication language: English

DOI: https://doi.org/10.1002/ejoc.201701630

Publication open access: Not open

Publication channel open access:


2H‐[1,3]Oxazino[3,2‐α]indolin‐4(3H)‐ones are easily prepared starting from indole and readily available 2‐methoxybenzoylchlorides by formation of the indole−acyl unit followed by a BBr3 deprotection/cyclization cascade.
A methodology for the synthesis of 2H‐[1,3]oxazino[3,2‐α]indolin‐4(3H)‐ones is reported. They are obtained from readily available materials by a facile synthetic procedure following either a two‐step cascade reaction or a step‐by‐step transformation. The target compounds represent a hitherto unreported class of indole derivatives with a novel kind of tris‐ or tetracyclic backbone.

Keywords: organic chemistry; chemical synthesis

Free keywords: compounds; Nitrogen heterocycles; Acid catalysis; Cyclization; Cascade reactions; Synthetic methods

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Ministry reporting: Yes

Reporting Year: 2018

JUFO rating: 1

Last updated on 2021-18-06 at 18:50