A1 Journal article (refereed)
High-affinity and selective detection of pyrophosphate in water by a resorcinarene salt receptor (2018)

Beyeh, N. K., Díez, I., Taimoory, S. M., Meister, D., Feig, A. I., Trant, J. F., Ras, R. H. A., & Rissanen, K. (2018). High-affinity and selective detection of pyrophosphate in water by a resorcinarene salt receptor. Chemical Science, 9(5), 1358-1367. https://doi.org/10.1039/C7SC05167K

JYU authors or editors

Publication details

All authors or editors: Beyeh, Ngong Kodiah; Díez, Isabel; Taimoory, S. Maryamdokht; Meister, Daniel; Feig, Andrew I.; Trant, John F.; Ras, Robin H. A.; Rissanen, Kari

Journal or series: Chemical Science

ISSN: 2041-6520

eISSN: 2041-6539

Publication year: 2018

Volume: 9

Issue number: 5

Pages range: 1358-1367

Publisher: Royal Society of Chemistry

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1039/C7SC05167K

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/57222

Abstract

Pyrophosphate (PPi) is a byproduct of DNA and RNA synthesis, and abnormal levels are indicative of disease. We report the high-affinity binding of PPi in water by N-alkyl ammonium resorcinarene chloride receptors. Experimental analysis using 1H and 31P NMR, isothermal titration calorimetry, mass spectrometry, and UV-vis spectroscopy all support exceptional selectivity of these systems for PPi in water. The measured affinity of K1 = 1.60 × 107 M−1 for PPi is three orders of magnitude larger than that observed for binding to another phosphate, ATP. This exceptional anion-binding affinity in water is explored through a detailed density functional theory computational study. These systems provide a promising avenue for the development of future innovative medical diagnostic tools.

Free keywords: pyrophosphate; resorcinarenes; receptors; molecular diagnostics

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Ministry reporting: Yes

Reporting Year: 2018

JUFO rating: 3