A1 Journal article (refereed)
Broad thermal tolerance is negatively correlated with virulence in an opportunistic bacterial pathogen (2018)


Ashrafi, R., Bruneaux, M., Sundberg, L.-R., Pulkkinen, K., Valkonen, J., & Ketola, T. (2018). Broad thermal tolerance is negatively correlated with virulence in an opportunistic bacterial pathogen. Evolutionary Applications, 11(9), 1700-1714. https://doi.org/10.1111/eva.12673


JYU authors or editors


Publication details

All authors or editorsAshrafi, Roghaieh; Bruneaux, Matthieu; Sundberg, Lotta-Riina; Pulkkinen, Katja; Valkonen, Janne; Ketola, Tarmo

Journal or seriesEvolutionary Applications

ISSN1752-4571

eISSN1752-4571

Publication year2018

Volume11

Issue number9

Pages range1700-1714

PublisherWiley-Blackwell Publishing, Inc.

Publication countryUnited States

Publication languageEnglish

DOIhttps://doi.org/10.1111/eva.12673

Research data linkhttps://doi.org/10.5061/dryad.858j5m7

Publication open accessOpenly available

Publication channel open accessOpen Access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/60061


Abstract

Predicting the effects of global increase in temperatures on disease virulence is challenging, especially for environmental opportunistic bacteria, because pathogen fitness may be differentially affected by temperature within and outside host environment. So far, there is very little empirical evidence on the connections between optimal temperature range and virulence in environmentally growing pathogens. Here, we explored whether the virulence of an environmentally growing opportunistic fish pathogen, Flavobacterium columnare, is malleable to evolutionary changes via correlated selection on thermal tolerance. To this end, we experimentally quantified the thermal performance curves (TPCs) for maximum biomass yield of 49 F. columnare isolates from eight different geographic locations in Finland over ten years (2003–2012). We also characterized virulence profiles of these strains in a zebra fish (Danio rerio) infection model. We show that virulence among the strains increased over the years, but thermal generalism, and in particular tolerance to higher temperatures, was negatively associated with virulence. Our data suggest that temperature has a strong effect on the pathogen genetic diversity and therefore presumably also on disease dynamics. However, the observed increase in frequency and severity of F. columnare epidemics over the last decade cannot be directly linked to bacterial evolution due to increased mean temperature, but is most likely associated with factors related to increased length of growing season, or other time‐dependent change in environment. Our study demonstrates that complex interactions between the host, the pathogen and the environment influence disease virulence of an environmentally growing opportunistic pathogen.


Keywordspathogensbacteriavirulenceheat resistanceclimate changes

Free keywordsthermal tolerance; opportunistic pathogen; thermal performance curves; climate change


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Ministry reportingYes

Reporting Year2018

JUFO rating1


Last updated on 2024-11-05 at 21:06