A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Physical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter (2020)

Strömmer, J., Davis, S. W., Henson, R. N., Tyler, L. K., Consortium, C. C. F. A. A. N., & Campbell, K. L. (2020). Physical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(2), 236-243. https://doi.org/10.1093/gerona/gly220

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Strömmer, Juho; Davis, Simon W.; Henson, Richard N.; Tyler, Lorraine K.; Consortium, Cambridge Centre for Ageing and Neuroscience; Campbell, Karen L.

Lehti tai sarja: Journals of Gerontology Series A: Biological Sciences and Medical Sciences

ISSN: 1079-5006

eISSN: 1758-535X

Julkaisuvuosi: 2020

Volyymi: 75

Lehden numero: 2

Artikkelin sivunumerot: 236-243

Kustantaja: Oxford University Press; The Gerontological Society of America

Julkaisumaa: Yhdysvallat (USA)

Julkaisun kieli: englanti

DOI: https://doi.org/10.1093/gerona/gly220

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/67740

Lisätietoja: Early view. Published: 04 October 2018.

Tiivistelmä

Physical activity has positive effects on brain health and cognitive function throughout the life span. Thus far, few studies have examined the effects of physical activity on white matter microstructure and psychomotor speed within the same, population-based sample (critical if conclusions are to extend to the wider population). Here, using diffusion tensor imaging and a simple reaction time task within a relatively large population-derived sample (N = 399; 18–87 years) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), we demonstrate that physical activity mediates the effect of age on white matter integrity, measured with fractional anisotropy. Higher self-reported daily physical activity was associated with greater preservation of white matter in several frontal tracts, including the genu of corpus callosum, uncinate fasciculus, external capsule, and anterior limb of the internal capsule. We also show that the age-related slowing is mediated by white matter integrity in the genu. Our findings contribute to a growing body of work, suggesting that a physically active lifestyle may protect against age-related structural disconnection and slowing.

YSO-asiasanat: aivot; ikääntyminen; fyysinen aktiivisuus

Vapaat asiasanat: brain aging; exercise; cognitive decline

Liittyvät organisaatiot

OKM-raportointi: Kyllä

Raportointivuosi: 2020

JUFO-taso: 3