A1 Journal article (refereed)
Physical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter (2020)


Strömmer, J., Davis, S. W., Henson, R. N., Tyler, L. K., Consortium, C. C. F. A. A. N., & Campbell, K. L. (2020). Physical Activity Predicts Population-Level Age-Related Differences in Frontal White Matter. Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 75(2), 236-243. https://doi.org/10.1093/gerona/gly220


JYU authors or editors


Publication details

All authors or editors: Strömmer, Juho; Davis, Simon W.; Henson, Richard N.; Tyler, Lorraine K.; Consortium, Cambridge Centre for Ageing and Neuroscience; Campbell, Karen L.

Journal or series: Journals of Gerontology Series A: Biological Sciences and Medical Sciences

ISSN: 1079-5006

eISSN: 1758-535X

Publication year: 2020

Volume: 75

Issue number: 2

Pages range: 236-243

Publisher: Oxford University Press; The Gerontological Society of America

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1093/gerona/gly220

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/67740

Additional information: Early view. Published: 04 October 2018.


Abstract

Physical activity has positive effects on brain health and cognitive function throughout the life span. Thus far, few studies have examined the effects of physical activity on white matter microstructure and psychomotor speed within the same, population-based sample (critical if conclusions are to extend to the wider population). Here, using diffusion tensor imaging and a simple reaction time task within a relatively large population-derived sample (N = 399; 18–87 years) from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN), we demonstrate that physical activity mediates the effect of age on white matter integrity, measured with fractional anisotropy. Higher self-reported daily physical activity was associated with greater preservation of white matter in several frontal tracts, including the genu of corpus callosum, uncinate fasciculus, external capsule, and anterior limb of the internal capsule. We also show that the age-related slowing is mediated by white matter integrity in the genu. Our findings contribute to a growing body of work, suggesting that a physically active lifestyle may protect against age-related structural disconnection and slowing.


Keywords: brain; ageing; physical activeness

Free keywords: brain aging; exercise; cognitive decline


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2020

JUFO rating: 3


Last updated on 2021-07-07 at 21:37