A1 Journal article (refereed)
Ion mobility-mass spectrometry of supramolecular complexes and assemblies (2019)

Kalenius, E., Groessl, M., & Rissanen, K. (2019). Ion mobility-mass spectrometry of supramolecular complexes and assemblies. Nature Reviews Chemistry, 3(1), 4-14. https://doi.org/10.1038/s41570-018-0062-2

JYU authors or editors

Publication details

All authors or editorsKalenius, Elina; Groessl, Michael; Rissanen, Kari

Journal or seriesNature Reviews Chemistry



Publication year2019


Issue number1

Pages range4-14

PublisherNature Publishing Group

Publication countryUnited Kingdom

Publication languageEnglish


Publication open accessNot open

Publication channel open access

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/64202


Despite their structural and functional differences, synthetic supramolecular assemblies share many similarities with biological assemblies, especially enzymes. The assemblies can be on the same length scale, and their structures and guest binding are typically governed by non-covalent interactions. Thus, only relatively weak interactions define the shape of a synthetic supramolecule or the secondary and tertiary structure of a protein, such that the resulting dynamism makes structure elucidation challenging. For biomolecules such as peptides, proteins, glycans and lipids this has often been tackled using ion mobility–mass spectrometry (IM-MS), whereby analyte ions are separated according to their gas-phase mobility and their mass-to-charge ratio. IM-MS is an established method in omics, separation sciences and small-molecule structural chemistry, but has only recently grown in popularity for the study of synthetic supramolecular assemblies in the gas phase. This Review describes IM-MS techniques and how they can help us understand the structures of molecular self-assemblies, host–guest complexes and metallosupramolecular complexes.

Keywordsmass spectrometrysupramolecular chemistry

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Ministry reportingYes

Reporting Year2019

JUFO rating1

Last updated on 2024-08-01 at 21:14