A1 Journal article (refereed)
Ion mobility-mass spectrometry of supramolecular complexes and assemblies (2019)
Kalenius, E., Groessl, M., & Rissanen, K. (2019). Ion mobility-mass spectrometry of supramolecular complexes and assemblies. Nature Reviews Chemistry, 3(1), 4-14. https://doi.org/10.1038/s41570-018-0062-2
JYU authors or editors
Publication details
All authors or editors: Kalenius, Elina; Groessl, Michael; Rissanen, Kari
Journal or series: Nature Reviews Chemistry
ISSN: 2397-3358
eISSN: 2397-3358
Publication year: 2019
Volume: 3
Issue number: 1
Pages range: 4-14
Publisher: Nature Publishing Group
Publication country: United Kingdom
Publication language: English
DOI: https://doi.org/10.1038/s41570-018-0062-2
Publication open access: Not open
Publication channel open access:
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/64202
Abstract
Despite their structural and functional differences, synthetic supramolecular assemblies share many similarities with biological assemblies, especially enzymes. The assemblies can be on the same length scale, and their structures and guest binding are typically governed by non-covalent interactions. Thus, only relatively weak interactions define the shape of a synthetic supramolecule or the secondary and tertiary structure of a protein, such that the resulting dynamism makes structure elucidation challenging. For biomolecules such as peptides, proteins, glycans and lipids this has often been tackled using ion mobility–mass spectrometry (IM-MS), whereby analyte ions are separated according to their gas-phase mobility and their mass-to-charge ratio. IM-MS is an established method in omics, separation sciences and small-molecule structural chemistry, but has only recently grown in popularity for the study of synthetic supramolecular assemblies in the gas phase. This Review describes IM-MS techniques and how they can help us understand the structures of molecular self-assemblies, host–guest complexes and metallosupramolecular complexes.
Keywords: mass spectrometry; supramolecular chemistry
Contributing organizations
Related projects
- Molekulaariset polyedrit ja metalliklust
- Kalenius, Elina
- Research Council of Finland
- Molecular Polyhedra and Metal Clusters in Gas Phase: Structures, Properties and Supramolecular Catalysis in Confined Space (research costs)
- Kalenius, Elina
- Research Council of Finland
Ministry reporting: Yes
Reporting Year: 2019
JUFO rating: 1