A1 Journal article (refereed)
Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies (2019)

Fries, M., Mertens, M., Teske, N., Kipp, M., Beyer, C., Willms, T., Valkonen, A., Rissanen, K., Albrecht, M., & Clarner, T. (2019). Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies. ACS Omega, 4(1), 1685-1689. https://doi.org/10.1021/acsomega.8b02523

JYU authors or editors

Publication details

All authors or editors: Fries, Martin; Mertens, Meike; Teske, Nico; Kipp, Markus; Beyer, Cordian; Willms, Thomas; Valkonen, Arto; Rissanen, Kari; Albrecht, Markus; Clarner, Tim

Journal or series: ACS Omega

ISSN: 2470-1343

eISSN: 2470-1343

Publication year: 2019

Volume: 4

Issue number: 1

Pages range: 1685-1689

Publisher: American Chemical Society

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1021/acsomega.8b02523

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/62592

Abstract

The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone.

Keywords: neurochemistry; pathogenesis; amines; chemical synthesis; in vitro method; synthesis

Free keywords: water-soluble cuprizone derivative; characterization; in Vitro studies

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Ministry reporting: Yes

Reporting Year: 2019

JUFO rating: 1