A1 Journal article (refereed)
Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies (2019)

Fries, M., Mertens, M., Teske, N., Kipp, M., Beyer, C., Willms, T., Valkonen, A., Rissanen, K., Albrecht, M., & Clarner, T. (2019). Water-Soluble Cuprizone Derivative: Synthesis, Characterization, and in Vitro Studies. ACS Omega, 4(1), 1685-1689. https://doi.org/10.1021/acsomega.8b02523

JYU authors or editors

Publication details

All authors or editorsFries, Martin; Mertens, Meike; Teske, Nico; Kipp, Markus; Beyer, Cordian; Willms, Thomas; Valkonen, Arto; Rissanen, Kari; Albrecht, Markus; Clarner, Tim

Journal or seriesACS Omega



Publication year2019


Issue number1

Pages range1685-1689

PublisherAmerican Chemical Society

Publication countryUnited States

Publication languageEnglish


Publication open accessOpenly available

Publication channel open accessOpen Access channel

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/62592


The cuprizone mouse model is one of the most accepted model systems for the investigation of oligodendrocyte degeneration, a process critically involved in the pathogenesis of diseases such as multiple sclerosis or schizophrenia. In order to substitute the in vivo experiments by in vitro approaches, the amine derivative BiMPi is introduced as a water-soluble alternative to cuprizone. Regarding superoxide dismutase activity, toxicity for oligodendrocytes, and disturbance of mitochondrial membrane potential, BiMPi shows similar in vitro effects as is observed in vivo for cuprizone.

Keywordsneurochemistrypathogenesisamineschemical synthesisin vitro methodsynthesis

Free keywordswater-soluble cuprizone derivative; characterization; in Vitro studies

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Ministry reportingYes

Reporting Year2019

JUFO rating1

Last updated on 2024-08-01 at 16:56