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Review of abnormal self-knowledge in major depressive disorder (2019)


Lou, Y., Lei, Y., Mei, Y., Leppänen, P. H. T., & Li, H. (2019). Review of abnormal self-knowledge in major depressive disorder. Frontiers in Psychiatry, 10, 130. doi:10.3389/fpsyt.2019.00130


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Lou, Yixue; Lei, Yi; Mei, Ying; Leppänen, Paavo H.T.; Li, Hong

Lehti tai sarja: Frontiers in Psychiatry

ISSN: 1664-0640

eISSN: 1664-0640

Julkaisuvuosi: 2019

Volyymi: 10

Lehden numero: 0

Artikkelinumero: 130

Kustantaja: Frontiers Research Foundation

Julkaisumaa: Sveitsi

Julkaisun kieli: englanti

DOI: https://doi.org/10.3389/fpsyt.2019.00130

Avoin saatavuus: Open access -julkaisukanavassa ilmestynyt julkaisu

Julkaisukanavan avoin saatavuus:

Julkaisun avoin saatavuus:

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/63477


Tiivistelmä

Background: Major depressive disorder (MDD) is an affective disorder that is harmful to both physical and mental health. Abnormal self-knowledge, which refers to abnormal judgments about oneself, is a core symptom of depression. However, little research has summarized how and why patients with MDD differ from healthy individuals in terms of self-knowledge.

Objective: To gain a better understanding of MDD, we reviewed previous studies that focused on the behavioral and neurological changes of self-knowledge in this illness.

Main Findings: On the behavioral level, depressed individuals exhibited negative self-knowledge in an explicit way, while more heterogeneous patterns were reported in implicit results. On the neurological level, depressed individuals, as compared with non-depressed controls, showed abnormal self-referential processing in both early perception and higher cognitive processing phases during the Self-Referential Encoding Task. Furthermore, fMRI studies have reported aberrant activity in the medial prefrontal cortex area for negative self-related items in depression. These results revealed several behavioral features and brain mechanisms underlying abnormal self-knowledge in depression.

Future Studies: The neural mechanism of implicit self-knowledge in MDD remains unclear. Future research should examine the importance of others' attitudes on the self-concept of individuals with MDD, and whether abnormal self-views may be modified through cognitive or pharmacological approaches. In addition, differences in abnormal self-knowledge due to genetic variation between depressed and non-depressed populations remain unconfirmed. Importantly, it remains unknown whether abnormal self-knowledge could be used as a specific marker to distinguish healthy individuals from those with MDD.

Conclusion: This review extends our understanding of the relationship between self-knowledge and depression by indicating several abnormalities among individuals with MDD and those who are at risk for this illness.


YSO-asiasanat: masennus; itsetuntemus; käyttäytymishäiriöt; neurologia

Vapaat asiasanat: major depressive disorder; abnormality; behavioral abnormality; neurological abnormality


Liittyvät organisaatiot

JYU-yksiköt:
Muut organisaatiot:


OKM-raportointi: Kyllä

Raportointivuosi: 2019

JUFO-taso: 1


Viimeisin päivitys 2021-22-02 klo 18:09