A2 Katsausartikkeli tieteellisessä aikausilehdessä
Review of abnormal self-knowledge in major depressive disorder (2019)
Lou, Y., Lei, Y., Mei, Y., Leppänen, P. H., & Li, H. (2019). Review of abnormal self-knowledge in major depressive disorder. Frontiers in Psychiatry, 10, Article 130. https://doi.org/10.3389/fpsyt.2019.00130
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Lou, Yixue; Lei, Yi; Mei, Ying; Leppänen, Paavo H.T.; Li, Hong
Lehti tai sarja: Frontiers in Psychiatry
ISSN: 1664-0640
eISSN: 1664-0640
Julkaisuvuosi: 2019
Volyymi: 10
Lehden numero: 0
Artikkelinumero: 130
Kustantaja: Frontiers Research Foundation
Julkaisumaa: Sveitsi
Julkaisun kieli: englanti
DOI: https://doi.org/10.3389/fpsyt.2019.00130
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/63477
Tiivistelmä
Objective: To gain a better understanding of MDD, we reviewed previous studies that focused on the behavioral and neurological changes of self-knowledge in this illness.
Main Findings: On the behavioral level, depressed individuals exhibited negative self-knowledge in an explicit way, while more heterogeneous patterns were reported in implicit results. On the neurological level, depressed individuals, as compared with non-depressed controls, showed abnormal self-referential processing in both early perception and higher cognitive processing phases during the Self-Referential Encoding Task. Furthermore, fMRI studies have reported aberrant activity in the medial prefrontal cortex area for negative self-related items in depression. These results revealed several behavioral features and brain mechanisms underlying abnormal self-knowledge in depression.
Future Studies: The neural mechanism of implicit self-knowledge in MDD remains unclear. Future research should examine the importance of others' attitudes on the self-concept of individuals with MDD, and whether abnormal self-views may be modified through cognitive or pharmacological approaches. In addition, differences in abnormal self-knowledge due to genetic variation between depressed and non-depressed populations remain unconfirmed. Importantly, it remains unknown whether abnormal self-knowledge could be used as a specific marker to distinguish healthy individuals from those with MDD.
Conclusion: This review extends our understanding of the relationship between self-knowledge and depression by indicating several abnormalities among individuals with MDD and those who are at risk for this illness.
YSO-asiasanat: masennus; itsetuntemus; käyttäytymishäiriöt; neurologia
Vapaat asiasanat: major depressive disorder; abnormality; behavioral abnormality; neurological abnormality
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2019
JUFO-taso: 1