A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Associations of overweight and metabolic health with successful aging : 32-year follow-up of the Helsinki Businessmen Study (2020)


Jyväkorpi, S. K., Urtamo, A., Strandberg, A. Y., von Bonsdorff, M., Salomaa, V., Kivimäki, M., Luotola, K., & Strandberg, T. E. (2020). Associations of overweight and metabolic health with successful aging : 32-year follow-up of the Helsinki Businessmen Study. Clinical Nutrition, 39(5), 1491-1496. https://doi.org/10.1016/j.clnu.2019.06.011


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Jyväkorpi, Satu K.; Urtamo, Annele; Strandberg, Arto Y.; von Bonsdorff, Mikaela; Salomaa, Veikko; Kivimäki, Mika; Luotola, Kari; Strandberg, Timo E.

Lehti tai sarja: Clinical Nutrition

ISSN: 0261-5614

eISSN: 1532-1983

Julkaisuvuosi: 2020

Volyymi: 39

Lehden numero: 5

Artikkelin sivunumerot: 1491-1496

Kustantaja: Elsevier BV

Julkaisumaa: Alankomaat

Julkaisun kieli: englanti

DOI: https://doi.org/10.1016/j.clnu.2019.06.011

Julkaisun avoin saatavuus: Ei avoin

Julkaisukanavan avoin saatavuus:

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/74558


Tiivistelmä

Background & aims
Prognostic significance of metabolically healthy overweight and obesity (MHO) is under debate. However the relationship between MHO and health-related quality of life (HRQoL) is less studied. We compared successful aging (longevity plus HRQoL) in men with MHO, metabolically healthy normal weight (MHN) and metabolically unhealthy overweight and obesity (MUO).

Methods
In the Helsinki Businessmen Study longitudinal cohort, consisting of men born 1919 to 1934. In 1985/86, overweight (BMI≥25 kg/m2) and metabolic health were determined in 1309 men (median age 60 years). HRQoL was assessed using RAND-36/SF-36 in 2000 and 2007, and all-cause mortality retrieved from registers up to 2018. The proportion of men reaching 90 years was also calculated.

Results
Of the men, 469 (35.8%), 538 (41.1%), 276 (21.1%), and 26 (2.0%) were MHN, MHO, MUO and MUN, respectively. During the 32-year follow-up, 72.3% men died. With MHN as reference, adjusted hazard ratio with all-cause mortality was 1.08 (95% confidence interval [CI] 0.93 to 1.27) for MHO, and 1.18 (95% CI 0.95 to 1.47) for MUO. During follow-up, 273 men reached 90 years. With MHN as reference, adjusted odds ratio for MHO was 0.82 (95% CI 0.59 to 1.14) and 0.62 (95% CI 0.41 to 0.95) for MUO. Men in MHN group scored generally highest in RAND-36 HRQoL subscales in 2000 and 2007, of those significantly better in Physical functioning, Role physical, Role emotional, Bodily Pain, and General health sub-scales compared to MHO group in 2000.

Conclusions
As compared to MHN, MHO in late midlife does not increase mortality, but impairs odds for successful aging.


YSO-asiasanat: elämänlaatu; ikääntyminen; ylipaino; aineenvaihdunta

Vapaat asiasanat: RAND-36; nonagenarians; successful aging; metabolically healthy overweight and obesity; metabolically unhealthy overweight and obesity


Liittyvät organisaatiot


OKM-raportointi: Kyllä

Raportointivuosi: 2020

JUFO-taso: 2


Viimeisin päivitys 2021-07-07 klo 21:35