A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
DNA methylation links prenatal smoking exposure to later life health outcomes in offspring (2019)


Wiklund, P., Karhunen, V., Richmond, R. C., Parmar, P., Rodriguez, A., De Silva, M., Wielscher, M., Rezwan, F. I., Richardson, T. G., Veijola, J., Herzig, K.-H., Holloway, J. W., Relton, C. L., Sebert, S., & Järvelin, M.-R. (2019). DNA methylation links prenatal smoking exposure to later life health outcomes in offspring. Clinical Epigenetics, 11, Article 97. https://doi.org/10.1186/s13148-019-0683-4


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Wiklund, Petri; Karhunen, Ville; Richmond, Rebecca C.; Parmar, Priyanka; Rodriguez, Alina; De Silva, Maneka; Wielscher, Matthias; Rezwan, Faisal I.; Richardson, Tom G.; Veijola, Juha; et al.

Lehti tai sarja: Clinical Epigenetics

ISSN: 1868-7075

eISSN: 1868-7083

Julkaisuvuosi: 2019

Volyymi: 11

Artikkelinumero: 97

Kustantaja: Biomed Central

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1186/s13148-019-0683-4

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/65110


Tiivistelmä

Background: Maternal smoking during pregnancy is associated with adverse offspring health outcomes across their life course. We hypothesize that DNA methylation is a potential mediator of this relationship.
Methods: We examined the association of prenatal maternal smoking with offspring blood DNA methylation in 2821 individuals (age 16 to 48 years) from five prospective birth cohort studies and perform Mendelian randomization and mediation analyses to assess whether methylation markers have causal effects on disease outcomes in the offspring.
Results: We identify 69 differentially methylated CpGs in 36 genomic regions (P value < 1 × 10−7) associated with exposure to maternal smoking in adolescents and adults. Mendelian randomization analyses provided evidence for a causal role of four maternal smoking-related CpG sites on an increased risk of inflammatory bowel disease or schizophrenia. Further mediation analyses showed some evidence of cg25189904 in GNG12 gene mediating the effect of exposure to maternal smoking on schizophrenia-related outcomes.
Conclusions: DNA methylation may represent a biological mechanism through which maternal smoking is associated with increased risk of psychiatric morbidity in the exposed offspring.


YSO-asiasanat: raskaus; tupakointi; terveysvaikutukset; kausaliteetti; DNA-metylaatio; kohorttitutkimus

Vapaat asiasanat: causality; DNA methylation; disease; life course; maternal smoking; mediation; persistence; pregnancy


Liittyvät organisaatiot


OKM-raportointi: Kyllä

Raportointivuosi: 2019

JUFO-taso: 1


Viimeisin päivitys 2024-08-01 klo 19:28