A1 Journal article (refereed)
Estrogen Regulates the Satellite Cell Compartment in Females (2019)

Collins, B. C., Arpke, R. W., Larson, A. A., Baumann, C. W., Xie, N., Cabelka, C. A., Nash, N. L., Juppi, H.-K., Laakkonen, E. K., Sipilä, S., Kovanen, V., Spangenburg, E. E., Kyba, M., & Lowe, D. A. (2019). Estrogen Regulates the Satellite Cell Compartment in Females. Cell Reports, 28(2), 368-381.e6. https://doi.org/10.1016/j.celrep.2019.06.025

JYU authors or editors

Juppi, Hanna-Kaarina
Laakkonen, Eija
Sipilä, Sarianna
Kovanen, Vuokko

Publication details

All authors or editors: Collins, Brittany C.; Arpke, Robert W.; Larson, Alexie A.; Baumann, Cory W.; Xie, Ning; Cabelka, Christine A.; Nash, Nardina L.; Juppi, Hanna-Kaarina; Laakkonen, Eija K.; Sipilä, Sarianna; et al.

Journal or series: Cell Reports

eISSN: 2211-1247

Publication year: 2019

Volume: 28

Issue number: 2

Pages range: 368-381.e6

Publisher: Cell Press

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1016/j.celrep.2019.06.025

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/65150

Abstract

Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing a greater deterioration in females around the time estrogen levels decrease at menopause. Here, we show that estrogen deficiency severely compromises the maintenance of muscle stem cells (i.e., satellite cells) as well as impairs self-renewal and differentiation into muscle fibers. Mechanistically, by hormone replacement, use of a selective estrogen-receptor modulator (bazedoxifene), and conditional estrogen receptor knockout, we implicate 17β-estradiol and satellite cell expression of estrogen receptor α and show that estrogen signaling through this receptor is necessary to prevent apoptosis of satellite cells. Early data from a biopsy study of women who transitioned from peri- to post-menopause are consistent with the loss of satellite cells coincident with the decline in estradiol in humans. Together, these results demonstrate an important role for estrogen in satellite cell maintenance and muscle regeneration in females.

Keywords: muscles; muscle cells; ageing; sex hormones; estrogens; estradiol

Free keywords: estradiol; muscle stem cells; ovarian hormones; quiescence; skeletal muscle

Fields of science: