A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood (2019)


Mäntyselkä, A., Haapala, E.A., Lindi, V., Häkkinen, M.R., Auriola S, Jääskeläinen, J., Lakka, T.A. (2019). Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood. Hormone Research in Paediatrics, 91(5), 329-335. https://doi.org/10.1159/000501719


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajatMäntyselkä, A.; Haapala, E.A.; Lindi, V.; Häkkinen, M.R.; Auriola S; Jääskeläinen, J.; Lakka, T.A.

Lehti tai sarjaHormone Research in Paediatrics

ISSN1663-2818

eISSN1663-2826

Julkaisuvuosi2019

Volyymi91

Lehden numero5

Artikkelin sivunumerot329-335

KustantajaS. Karger

JulkaisumaaSveitsi

Julkaisun kielienglanti

DOIhttps://doi.org/10.1159/000501719

Julkaisun avoin saatavuusEi avoin

Julkaisukanavan avoin saatavuus

Julkaisu on rinnakkaistallennettu (JYX)https://jyx.jyu.fi/handle/123456789/65348


Tiivistelmä

Background: Little is known about the association between adrenarche and cognition in general populations of children. We therefore studied the associations of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), testosterone, insulin-like growth factor-1 (IGF-1), and adrenarche with cognition among prepubertal children. Methods: These cross-sectional analyses are based on baseline data of the Physical Activity and Nutrition in Children Study. A total of 387 children (183 girls, 204 boys) were included in the analyses. Raven’s Coloured Progressive Matrices (CPM) score was used to assess nonverbal reasoning. Serum adrenal androgens and IGF-1 concentrations were measured and clinical signs of androgen action were evaluated. Results: Higher IGF-1 among boys (β = 0.149, p =0.033) was related to a better Raven’s CPM score after adjustment for age and parental education. Adrenal androgens in girls or boys or IGF-1 in girls were not associated with the score. There were no differences in Raven’s CPM score between children with biochemical adrenarche (DHEAS ≥1.08 µmol/L; ≥40 µg/dL) or with clinical signs of androgen action and children without them. Conclusion: The results suggest that higher serum IGF-1 among boys is related to better cognition in prepubertal children. We could not provide evidence for the associations of adrenal maturation with cognition in prepubertal children.


YSO-asiasanathormonaaliset tekijätkasvuhormonitsteroiditandrogeenitadrenarkekognitiokognitiivinen kehityslapset (ikäryhmät)

Vapaat asiasanatDHEAS; insulin-like growth factor-1; adrenarche; cognition


Liittyvät organisaatiot


OKM-raportointiKyllä

Raportointivuosi2019

JUFO-taso1


Viimeisin päivitys 2024-11-05 klo 19:06