A1 Journal article (refereed)
Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood (2019)

Mäntyselkä, A., Haapala, E.A., Lindi, V., Häkkinen, M.R., Auriola S, Jääskeläinen, J., Lakka, T.A. (2019). Associations of IGF-1 and Adrenal Androgens with Cognition in Childhood. Hormone Research in Paediatrics, 91(5), 329-335. https://doi.org/10.1159/000501719

JYU authors or editors

Publication details

All authors or editorsMäntyselkä, A.; Haapala, E.A.; Lindi, V.; Häkkinen, M.R.; Auriola S; Jääskeläinen, J.; Lakka, T.A.

Journal or seriesHormone Research in Paediatrics



Publication year2019


Issue number5

Pages range329-335

PublisherS. Karger

Publication countrySwitzerland

Publication languageEnglish


Publication open accessNot open

Publication channel open access

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/65348


Background: Little is known about the association between adrenarche and cognition in general populations of children. We therefore studied the associations of dehydroepiandrosterone sulfate (DHEAS), androstenedione (A4), testosterone, insulin-like growth factor-1 (IGF-1), and adrenarche with cognition among prepubertal children. Methods: These cross-sectional analyses are based on baseline data of the Physical Activity and Nutrition in Children Study. A total of 387 children (183 girls, 204 boys) were included in the analyses. Raven’s Coloured Progressive Matrices (CPM) score was used to assess nonverbal reasoning. Serum adrenal androgens and IGF-1 concentrations were measured and clinical signs of androgen action were evaluated. Results: Higher IGF-1 among boys (β = 0.149, p =0.033) was related to a better Raven’s CPM score after adjustment for age and parental education. Adrenal androgens in girls or boys or IGF-1 in girls were not associated with the score. There were no differences in Raven’s CPM score between children with biochemical adrenarche (DHEAS ≥1.08 µmol/L; ≥40 µg/dL) or with clinical signs of androgen action and children without them. Conclusion: The results suggest that higher serum IGF-1 among boys is related to better cognition in prepubertal children. We could not provide evidence for the associations of adrenal maturation with cognition in prepubertal children.

Keywordshormonal factorsgrowth hormonessteroidsandrogensadrenarchecognitioncognitive developmentchildren (age groups)

Free keywordsDHEAS; insulin-like growth factor-1; adrenarche; cognition

Contributing organizations

Ministry reportingYes

Reporting Year2019

JUFO rating1

Last updated on 2024-11-05 at 19:06