A1 Journal article (refereed)
Midlife Cardiovascular Status and Old Age Physical Functioning Trajectories in Older Businessmen (2019)
von Bonsdorff, M. B., Haapanen, M. J., Törmäkangas, T., Pitkälä, K. H., Stenholm, S., & Strandberg, T. E. (2019). Midlife Cardiovascular Status and Old Age Physical Functioning Trajectories in Older Businessmen. Journal of the American Geriatrics Society, 67(12), 2490-2496. https://doi.org/10.1111/jgs.16150
JYU authors or editors
Publication details
All authors or editors: von Bonsdorff, Mikaela B.; Haapanen, Markus J.; Törmäkangas, Timo; Pitkälä, Kaisu H.; Stenholm, Sari; Strandberg, Timo E.
Journal or series: Journal of the American Geriatrics Society
ISSN: 0002-8614
eISSN: 1532-5415
Publication year: 2019
Volume: 67
Issue number: 12
Pages range: 2490-2496
Publisher: Wiley-Blackwell Publishing, Inc.
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1111/jgs.16150
Publication open access: Not open
Publication channel open access:
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/66702
Abstract
DESIGN. Prospective cohort study.
SETTING. Helsinki Businessmen Study.
PARTICIPANTS. We studied white men born between 1919 and 1934 in the Helsinki Businessmen Study (HBS, initial n = 3490).
MEASUREMENTS. Three CVD status groups were formed based on clinical measurements carried out in 1974: signs of CVD (diagnosed clinically or with changes in ECG, chronic disease present or used medication, n = 563); healthy and low CVD risk (n = 593) and high CVD risk (n = 1222). Of them, 1560 men had data on physical functioning from at least one of four data collection waves between 2000‐2010. Ten questions from the RAND‐36 (SF‐36) survey were used to construct physical functioning trajectories with latent class growth mixture models. Mortality was accounted for in competing risk models.
RESULTS. A five‐class solution provided the optimal number of trajectories: “intact,” “high stable,” “high and declining,” “intermediate and declining,” and “consistently low” functioning. Compared with low CVD risk, high CVD risk in midlife decreased the risk of being classified into the intact (fully adjusted β = −3.98; standard error = 2.0; P = .046) relative to the consistently low physical functioning trajectory. Compared with low CVD risk, those with signs of CVD were less likely to follow the intact, high stable, or high and declining relative to the consistently low trajectory (all P < .018).
CONCLUSION. Among businessmen, a more favorable CVD profile in midlife was associated with better development of physical functioning in old age.
Keywords: cardiovascular diseases; physical functioning; forecasts; ageing
Free keywords: cardiovascular health; physical functioning; trajectories; growth mixture model; life course epidemiology; healthy aging
Contributing organizations
Related projects
- Path and structural equation models of high-dimensional data in bioinformatics with applications for aging research
- Törmäkangas, Timo
- Research Council of Finland
Ministry reporting: Yes
Reporting Year: 2019
JUFO rating: 3