A1 Journal article (refereed)
Deviance detection in sound frequency in simple and complex sounds in urethane-anesthetized rats (2021)


Yang, T., Hämäläinen, J., Lohvansuu, K., Lipponen, A., Penttonen, M., & Astikainen, P. (2021). Deviance detection in sound frequency in simple and complex sounds in urethane-anesthetized rats. Hearing Research, 399, Article 107814. https://doi.org/10.1016/j.heares.2019.107814


JYU authors or editors


Publication details

All authors or editorsYang, Tiantian; Hämäläinen, Jarmo; Lohvansuu, Kaisa; Lipponen, Arto; Penttonen, Markku; Astikainen, Piia

Journal or seriesHearing Research

ISSN0378-5955

eISSN1878-5891

Publication year2021

Volume399

Article number107814

PublisherElsevier

Publication countryNetherlands

Publication languageEnglish

DOIhttps://doi.org/10.1016/j.heares.2019.107814

Publication open accessNot open

Publication channel open access

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/73630


Abstract

Mismatch negativity (MMN), which is an electrophysiological response demonstrated in humans and animals, reflects memory-based deviance detection in a series of sounds. However, only a few studies on rodents have used control conditions that were sufficient in eliminating confounding factors that could also explain differential responses to deviant sounds. Furthermore, it is unclear if change detection occurs similarly for sinusoidal and complex sounds. In this study, we investigated frequency change detection in urethane-anesthetized rats by recording local-field potentials from the dura above the auditory cortex. We studied change detection in sinusoidal and complex sounds in a series of experiments, controlling for sound frequency, probability, and pattern in a series of sounds. For sinusoidal sounds, the MMN controlled for frequency, adaptation, and pattern, was elicited at approximately 200 ms onset latency. For complex sounds, the MMN controlled for frequency and adaptation, was elicited at 60 ms onset latency. Sound frequency affected the differential responses. MMN amplitude was larger for the sinusoidal sounds than for the complex sounds. These findings indicate the importance of controlling for sound frequency and stimulus probabilities, which have not been fully controlled for in most previous animal and human studies. Future studies should confirm the preference for sinusoidal sounds over complex sounds in rats.


Keywordssense of hearingcerebral cortexsound (physical phenomena)frequencyelectrophysiologyperception (activity)stimuli (role related to effect)interferencesanimal disease models

Free keywordsauditory cortex; change detection; local-field potentials; mismatch negativity; rats


Contributing organizations


Related projects


Related research datasets


Ministry reportingYes

Reporting Year2021

JUFO rating2


Last updated on 2024-10-03 at 19:56