A1 Journal article (refereed)
Deviance detection in sound frequency in simple and complex sounds in urethane-anesthetized rats (2021)

Yang, T., Hämäläinen, J., Lohvansuu, K., Lipponen, A., Penttonen, M., & Astikainen, P. (2021). Deviance detection in sound frequency in simple and complex sounds in urethane-anesthetized rats. Hearing Research, 399, Article 107814. https://doi.org/10.1016/j.heares.2019.107814

JYU authors or editors

Yang, Tiantian
Hämäläinen, Jarmo
Lohvansuu, Kaisa
Lipponen, Arto
Penttonen, Markku
Astikainen, Piia

Publication details

All authors or editors: Yang, Tiantian; Hämäläinen, Jarmo; Lohvansuu, Kaisa; Lipponen, Arto; Penttonen, Markku; Astikainen, Piia

Journal or series: Hearing Research

ISSN: 0378-5955

eISSN: 1878-5891

Publication year: 2021

Volume: 399

Article number: 107814

Publisher: Elsevier

Publication country: Netherlands

Publication language: English

DOI: https://doi.org/10.1016/j.heares.2019.107814

Publication open access: Not open

Publication channel open access:

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/73630

Abstract

Mismatch negativity (MMN), which is an electrophysiological response demonstrated in humans and animals, reflects memory-based deviance detection in a series of sounds. However, only a few studies on rodents have used control conditions that were sufficient in eliminating confounding factors that could also explain differential responses to deviant sounds. Furthermore, it is unclear if change detection occurs similarly for sinusoidal and complex sounds. In this study, we investigated frequency change detection in urethane-anesthetized rats by recording local-field potentials from the dura above the auditory cortex. We studied change detection in sinusoidal and complex sounds in a series of experiments, controlling for sound frequency, probability, and pattern in a series of sounds. For sinusoidal sounds, the MMN controlled for frequency, adaptation, and pattern, was elicited at approximately 200 ms onset latency. For complex sounds, the MMN controlled for frequency and adaptation, was elicited at 60 ms onset latency. Sound frequency affected the differential responses. MMN amplitude was larger for the sinusoidal sounds than for the complex sounds. These findings indicate the importance of controlling for sound frequency and stimulus probabilities, which have not been fully controlled for in most previous animal and human studies. Future studies should confirm the preference for sinusoidal sounds over complex sounds in rats.

Keywords: sense of hearing; cerebral cortex; sound (physical phenomena); frequency; electrophysiology; perception (activity); stimuli (role related to effect); interferences; animal disease models