A2 Katsausartikkeli tieteellisessä aikausilehdessä
FinnTwin12 Cohort : An Updated Review (2019)

Rose, R. J., Salvatore, J. E., Aaltonen, S., Barr, P. B., Bogl, L. H., Byers, H. A., Heikkilä, K., Korhonen, T., Latvala, A., Palviainen, T., Ranjit, A., Whipp, A. M., Pulkkinen, L., Dick, D. M., & Kaprio, J. (2019). FinnTwin12 Cohort : An Updated Review. Twin Research and Human Genetics, 22(5), 302-311. https://doi.org/10.1017/thg.2019.83

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Rose, Richard J.; Salvatore, Jessica E.; Aaltonen, Sari; Barr, Peter B.; Bogl, Leonie H.; Byers, Holly A.; Heikkilä, Kauko; Korhonen, Tellervo; Latvala, Antti; Palviainen, Teemu; et al.

Lehti tai sarja: Twin Research and Human Genetics

ISSN: 1832-4274

eISSN: 1839-2628

Julkaisuvuosi: 2019

Volyymi: 22

Lehden numero: 5

Artikkelin sivunumerot: 302-311

Kustantaja: Cambridge University Press

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1017/thg.2019.83

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/67091

Tiivistelmä

This review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage, we conducted multiwave questionnaire research enrolling all eligible twins born in Finland during 1983–1987 along with their biological parents. In stage 2, we intensively studied a subset of these twins with in-school assessments at age 12 and semistructured poly-diagnostic interviews at age 14. At baseline, parents of intensively studied twins were administered the adult version of the interview. Laboratory studies with repeat interviews, neuropsychological tests, and collection of DNA were made of intensively studied twins during follow-up in early adulthood. The basic aim of the FT12 study design was to obtain information on individual, familial and school/neighborhood risks for substance use/abuse prior to the onset of regular tobacco and alcohol use and then track trajectories of use and abuse and their consequences into adulthood. But the longitudinal assessments were not narrowly limited to this basic aim, and with multiwave, multirater assessments from ages 11 to 12, the study has created a richly informative data set for analyses of gene–environment interactions of both candidate genes and genomewide measures with measured risk-relevant environments. Because 25 years have elapsed since the start of the study, we are planning a fifth-wave follow-up assessment.

YSO-asiasanat: kaksostutkimus; kohorttitutkimus; pitkittäistutkimus; terveysriskit; alkoholinkäyttö; tupakointi; ruokavaliot; fyysinen aktiivisuus; mielenterveys; perinnöllisyystiede; epigenetiikka; fenotyyppi

Vapaat asiasanat: longitudinal twin-family study; alcohol; diet; diverse phenotypes; epigenetics; genetics; mental health; metabolomics; physical activity; smoking; twins; two-stage design

Liittyvät organisaatiot

OKM-raportointi: Kyllä

Raportointivuosi: 2019

JUFO-taso: 1