A2 Review article, Literature review, Systematic review
FinnTwin12 Cohort : An Updated Review (2019)


Rose, R. J., Salvatore, J. E., Aaltonen, S., Barr, P. B., Bogl, L. H., Byers, H. A., Heikkilä, K., Korhonen, T., Latvala, A., Palviainen, T., Ranjit, A., Whipp, A. M., Pulkkinen, L., Dick, D. M., & Kaprio, J. (2019). FinnTwin12 Cohort : An Updated Review. Twin Research and Human Genetics, 22(5), 302-311. https://doi.org/10.1017/thg.2019.83


JYU authors or editors


Publication details

All authors or editors: Rose, Richard J.; Salvatore, Jessica E.; Aaltonen, Sari; Barr, Peter B.; Bogl, Leonie H.; Byers, Holly A.; Heikkilä, Kauko; Korhonen, Tellervo; Latvala, Antti; Palviainen, Teemu; et al.

Journal or series: Twin Research and Human Genetics

ISSN: 1832-4274

eISSN: 1839-2628

Publication year: 2019

Volume: 22

Issue number: 5

Pages range: 302-311

Publisher: Cambridge University Press

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1017/thg.2019.83

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/67091


Abstract

This review offers an update on research conducted with FinnTwin12 (FT12), the youngest of the three Finnish Twin Cohorts. FT12 was designed as a two-stage study. In the first stage, we conducted multiwave questionnaire research enrolling all eligible twins born in Finland during 1983–1987 along with their biological parents. In stage 2, we intensively studied a subset of these twins with in-school assessments at age 12 and semistructured poly-diagnostic interviews at age 14. At baseline, parents of intensively studied twins were administered the adult version of the interview. Laboratory studies with repeat interviews, neuropsychological tests, and collection of DNA were made of intensively studied twins during follow-up in early adulthood. The basic aim of the FT12 study design was to obtain information on individual, familial and school/neighborhood risks for substance use/abuse prior to the onset of regular tobacco and alcohol use and then track trajectories of use and abuse and their consequences into adulthood. But the longitudinal assessments were not narrowly limited to this basic aim, and with multiwave, multirater assessments from ages 11 to 12, the study has created a richly informative data set for analyses of gene–environment interactions of both candidate genes and genomewide measures with measured risk-relevant environments. Because 25 years have elapsed since the start of the study, we are planning a fifth-wave follow-up assessment.


Keywords: twin research; cohort study; longitudinal research; health risks; alcohol use; smoking; diets; physical activeness; mental health; genetics; epigenetics; phenotype

Free keywords: longitudinal twin-family study; alcohol; diet; diverse phenotypes; epigenetics; genetics; mental health; metabolomics; physical activity; smoking; twins; two-stage design


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2019

JUFO rating: 1


Last updated on 2021-28-06 at 17:05