A1 Journal article (refereed)
Fat oxidation at rest and during exercise in male monozygotic twins (2019)


Karppinen, J. E., Rottensteiner, M., Wiklund, P., Hämäläinen, K., Laakkonen, E. K., Kaprio, J., Kainulainen, H., & Kujala, U. M. (2019). Fat oxidation at rest and during exercise in male monozygotic twins. European Journal of Applied Physiology, 119(11-12), 2711-2722. https://doi.org/10.1007/s00421-019-04247-x


JYU authors or editors


Publication details

All authors or editors: Karppinen, Jari E.; Rottensteiner, Mirva; Wiklund, Petri; Hämäläinen, Kaisa; Laakkonen, Eija K.; Kaprio, Jaakko; Kainulainen, Heikki; Kujala, Urho M.

Journal or series: European Journal of Applied Physiology

ISSN: 1439-6319

eISSN: 1439-6327

Publication year: 2019

Volume: 119

Issue number: 11-12

Pages range: 2711-2722

Publisher: Springer

Publication country: Germany

Publication language: English

DOI: https://doi.org/10.1007/s00421-019-04247-x

Publication open access: Openly available

Publication channel open access: Partially open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/66188


Abstract

Purpose. We aimed to investigate if hereditary factors, leisure-time physical activity (LTPA) and metabolic health interact with resting fat oxidation (RFO) and peak fat oxidation (PFO) during ergometer cycling.
Methods. We recruited 23 male monozygotic twin pairs (aged 32–37 years) and determined their RFO and PFO with indirect calorimetry for 21 and 19 twin pairs and for 43 and 41 twin individuals, respectively. Using physical activity interviews and the Baecke questionnaire, we identified 10 twin pairs as LTPA discordant for the past 3 years. Of the twin pairs, 8 pairs participated in both RFO and PFO measurements, and 2 pairs participated in either of the measurements. We quantified the participants’ metabolic health with a 2-h oral glucose tolerance test.
Results. Fat oxidation within co-twins was correlated at rest [intraclass correlation coefficient (ICC) = 0.54, 95% confidence interval (CI) 0.15–0.78] and during exercise (ICC = 0.67, 95% CI 0.33–0.86). The LTPA-discordant pairs had no pairwise differences in RFO or PFO. In the twin individual-based analysis, PFO was positively correlated with the past 12-month LTPA (r = 0.26, p = 0.034) and the Baecke score (r = 0.40, p = 0.022) and negatively correlated with the area under the curve of insulin (r = − 0.42, p = 0.015) and glucose (r = − 0.31, p = 0.050) during the oral glucose tolerance test.
Conclusions. Hereditary factors were more important than LTPA for determining fat oxidation at rest and during exercise. Additionally, PFO, but not RFO, was associated with better metabolic health.


Keywords: physical activeness; physical training; metabolism; lipids; oxidation (passive); glucose; twin research

Free keywords: twins; exercise; lipid metabolism; oral glucose tolerance


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2019

JUFO rating: 1


Last updated on 2021-09-08 at 16:11