A1 Journal article (refereed)
Event-related potentials to task-irrelevant sad faces as a state marker of depression (2020)


Ruohonen, E. M., Alhainen, V., & Astikainen, P. (2020). Event-related potentials to task-irrelevant sad faces as a state marker of depression. Biological Psychology, 149, Article 107806. https://doi.org/10.1016/j.biopsycho.2019.107806


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Publication details

All authors or editorsRuohonen, Elisa M.; Alhainen, Veera; Astikainen, Piia

Journal or seriesBiological Psychology

ISSN0301-0511

eISSN1873-6246

Publication year2020

Volume149

Article number107806

PublisherElsevier

Publication countryNetherlands

Publication languageEnglish

DOIhttps://doi.org/10.1016/j.biopsycho.2019.107806

Publication open accessNot open

Publication channel open access

Publication is parallel published (JYX)https://jyx.jyu.fi/handle/123456789/66388


Abstract

Negative bias in face processing has been demonstrated in depression, but there are no longitudinal investigations of negative bias in symptom reduction. We recorded event-related potentials (P1 and N170) to task-irrelevant facial expressions in depressed participants who were later provided with a psychological intervention and in never depressed control participants. Follow-up measurements were conducted for the depressed group two and 39 months later. Negative bias was found specifically in the depression group, and was demonstrated as enlarged P1 amplitude to sad faces, which normalized in the follow-up measurements when the participants had fewer symptoms. Because the P1 amplitude recorded at the baseline did not differ between the depression group that recovered and the group that did not recover after the intervention, this brain response did not show potential as a biomarker for treatment response. It could have potential, however, to serve as a state-marker of depression.


Keywordsdepression (mental disorders)facefacial expressionsbrain researchcognitive neurosciencediagnosisintervention

Free keywordsdepression; ERP; negative bias; N170; P1; preattentive face processing


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Ministry reportingYes

VIRTA submission year2020

JUFO rating2


Last updated on 2024-12-10 at 05:30