A1 Journal article (refereed)
Event-related potentials to task-irrelevant sad faces as a state marker of depression (2020)
Ruohonen, E. M., Alhainen, V., & Astikainen, P. (2020). Event-related potentials to task-irrelevant sad faces as a state marker of depression. Biological Psychology, 149, Article 107806. https://doi.org/10.1016/j.biopsycho.2019.107806
JYU authors or editors
Publication details
All authors or editors: Ruohonen, Elisa M.; Alhainen, Veera; Astikainen, Piia
Journal or series: Biological Psychology
ISSN: 0301-0511
eISSN: 1873-6246
Publication year: 2020
Volume: 149
Article number: 107806
Publisher: Elsevier
Publication country: Netherlands
Publication language: English
DOI: https://doi.org/10.1016/j.biopsycho.2019.107806
Publication open access: Not open
Publication channel open access:
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/66388
Abstract
Negative bias in face processing has been demonstrated in depression, but there are no longitudinal investigations of negative bias in symptom reduction. We recorded event-related potentials (P1 and N170) to task-irrelevant facial expressions in depressed participants who were later provided with a psychological intervention and in never depressed control participants. Follow-up measurements were conducted for the depressed group two and 39 months later. Negative bias was found specifically in the depression group, and was demonstrated as enlarged P1 amplitude to sad faces, which normalized in the follow-up measurements when the participants had fewer symptoms. Because the P1 amplitude recorded at the baseline did not differ between the depression group that recovered and the group that did not recover after the intervention, this brain response did not show potential as a biomarker for treatment response. It could have potential, however, to serve as a state-marker of depression.
Keywords: depression (mental disorders); face; facial expressions; brain research; cognitive neuroscience; diagnosis; intervention
Free keywords: depression; ERP; negative bias; N170; P1; preattentive face processing
Contributing organizations
Related projects
- Neural markers of depression
- Vuoriainen, Elisa
- Finnish Cultural Foundation
Ministry reporting: Yes
VIRTA submission year: 2020
JUFO rating: 2