A1 Journal article (refereed)
Bacteriophage Adherence to Mucus Mediates Preventive Protection against Pathogenic Bacteria (2019)


Almeida, Gabriel M. F.; Laanto, Elina; Ashrafi, Roghaleh; Sundberg, Lotta-Riina (2019). Bacteriophage Adherence to Mucus Mediates Preventive Protection against Pathogenic Bacteria. mBio, 10 (6), e01984-19. DOI: 10.1128/mBio.01984-19


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Publication details

All authors or editors: Almeida, Gabriel M. F.; Laanto, Elina; Ashrafi, Roghaleh; Sundberg, Lotta-Riina

Journal or series: mBio

ISSN: 2161-2129

eISSN: 2150-7511

Publication year: 2019

Volume: 10

Issue number: 6

Article number: e01984-19

Publisher: American Society for Microbiology

Publication country: United States

Publication language: English

DOI: https://doi.org/10.1128/mBio.01984-19

Open Access: Publication published in an open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/66452


Abstract

Metazoans were proposed to host bacteriophages on their mucosal surfaces in a symbiotic relationship, where phages provide an external immunity against bacterial infections and the metazoans provide phages a medium for interacting with bacteria. However, scarce empirical evidence and model systems have left the phage-mucus interaction poorly understood. Here, we show that phages bind both to porcine mucus and to rainbow trout (Oncorhynchus mykiss) primary mucus, persist up to 7 days in the mucosa, and provide protection against Flavobacterium columnare. Also, exposure to mucus changes the bacterial phenotype by increasing bacterial virulence and susceptibility to phage infections. This trade-off in bacterial virulence reveals ecological benefit of maintaining phages in the metazoan mucosal surfaces. Tests using other phage-bacterium pairs suggest that phage binding to mucus may be widespread in the biosphere, indicating its importance for disease, ecology, and evolution. This phenomenon may have significant potential to be exploited in preventive phage therapy.


Keywords: bacteria; virulence; bacteriophages; phage therapy; mucous membranes; fish diseases

Free keywords: bacterial virulence; bacteriophage therapy; bacteriophages; hostpathogen interactions; mucosal pathogens


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Ministry reporting: Yes

Reporting Year: 2019

JUFO rating: 1


Last updated on 2020-18-08 at 13:05