A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood (2019)


Westberg, A. P., Kautiainen, H., Salonen, M. K., Kajantie, E., von Bonsdorff, M., & Eriksson, J. G. (2019). The impact of maternal weight in pregnancy on glucose metabolism in non-diabetic offspring in late adulthood. Diabetes Research and Clinical Practice, 158, Article 107926. https://doi.org/10.1016/j.diabres.2019.107926


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Westberg, Anna P.; Kautiainen, Hannu; Salonen, Minna K.; Kajantie, Eero; von Bonsdorff, Mikaela; Eriksson, Johan G.

Lehti tai sarja: Diabetes Research and Clinical Practice

ISSN: 0168-8227

eISSN: 1872-8227

Julkaisuvuosi: 2019

Volyymi: 158

Artikkelinumero: 107926

Kustantaja: Elsevier

Julkaisumaa: Alankomaat

Julkaisun kieli: englanti

DOI: https://doi.org/10.1016/j.diabres.2019.107926

Julkaisun avoin saatavuus: Ei avoin

Julkaisukanavan avoin saatavuus:

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/66538


Tiivistelmä

Aims
We aimed to examine the association between maternal adiposity and glucose metabolism in adult offspring without diabetes, simultaneous taking offspring own adiposity into account.

Methods
This longitudinal birth cohort study (Helsinki Birth Cohort Study) included 1,440 non-diabetic subjects examined at a mean age of 62 years. Subjects were divided into quartiles according to maternal body mass index (BMI). The impact of maternal BMI on offspring body composition was also studied.

Results
There were no differences in fasting glucose between the groups. In men, maternal BMI was inversely associated with mean 2-hour glucose concentration after a 75 g oral glucose tolerance test (p<0.001) and mean homeostatic model assessment of insulin resistance (HOMA-IR) (p=0.049). According to the subjects’ own BMI, high maternal BMI was associated with lower 2-hour glucose concentrations only in non-obese men and with lower HOMA-IR only in obese men. Maternal BMI was not associated with glucose concentrations nor with HOMA-IR in women. In addition, maternal BMI was positively associated with a higher offspring lean body mass in men.

Conclusions
High maternal BMI was associated with lower 2-hour plasma glucose concentration, especially in non-obese men. Offspring lean body mass may be a mediating factor for the association.


YSO-asiasanat: raskaus; ylipaino; lihavuus; äidit; lapset (perheenjäsenet); aineenvaihdunta; aineenvaihduntahäiriöt; insuliiniresistenssi

Vapaat asiasanat: maternal obesity; offspring health; BMI; glucose metabolism; insulin sensitivity


Liittyvät organisaatiot


OKM-raportointi: Kyllä

Raportointivuosi: 2019

JUFO-taso: 1


Viimeisin päivitys 2021-25-08 klo 12:41