A1 Journal article (refereed)
Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children (2020)


Haapala, Eero A.; Wiklund, Petri; Lintu, Niina; Tompuri, Tuomo; Väistö, Juuso; Finni, Taija; Tarkka, Ina M.; Kemppainen, Titta; Barker, Alan R.; Ekelund, Ulf; Brage, Soren; Lakka, Timo A. (2020). Cardiorespiratory Fitness, Physical Activity, and Insulin Resistance in Children. Medicine and Science in Sports and Exercise, 52 (5), 1144-1152. DOI: 10.1249/MSS.0000000000002216


JYU authors or editors


Publication details

All authors or editors: Haapala, Eero A.; Wiklund, Petri; Lintu, Niina; Tompuri, Tuomo; Väistö, Juuso; Finni, Taija; Tarkka, Ina M.; Kemppainen, Titta; Barker, Alan R.; Ekelund, Ulf; et al.

Journal or series: Medicine and Science in Sports and Exercise

ISSN: 0195-9131

eISSN: 1530-0315

Publication year: 2020

Volume: 52

Issue number: 5

Pages range: 1144-1152

Publisher: Lippincott Williams & Wilkins

Publication country: United States

Publication language: English

DOI: http://doi.org/10.1249/MSS.0000000000002216

Open Access: Publication channel is not openly available

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/66727

Publication is parallel published: https://www.repository.cam.ac.uk/handle/1810/299505


Abstract

Purpose Few studies have investigated the independent and joint associations of cardiorespiratory fitness (CRF) and body fat percentage (BF%) with insulin resistance in children. We investigated the independent and combined associations of CRF and BF% with fasting glycaemia and insulin resistance and their interactions with physical activity (PA) and sedentary time among 452 children aged 6–8 years.
Methods We assessed CRF with a maximal cycle ergometer exercise test and used allometrically scaled maximal power output (Wmax) for lean body mass (LM1.13) and body mass (BM1) as measures of CRF. BF% and LM were measured by dual-energy X-ray absorptiometry, fasting glycaemia by fasting plasma glucose, and insulin resistance by fasting serum insulin and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR). PA energy expenditure (PAEE), moderate-to-vigorous PA (MVPA), and sedentary time were assessed by combined movement and heart rate sensor.
Results Wmax/LM1.13 was not associated with glucose (β=0.065, 95% CI=-0.031 to 0.161), insulin (β=-0.079, 95% CI=-0.172 to 0.015), or HOMA-IR (β=-0.065, 95% CI=-0.161 to 0.030). Wmax/BM1 was inversely associated with insulin (β=-0.289, 95% CI=-0.377 to -0.200) and HOMA-IR (β=-0.269, 95% CI=-0.359 to -0.180). BF% was directly associated with insulin (β=0.409, 95% CI=0.325 to 0.494) and HOMA-IR (β=0.390, 95% CI=0.304 to 0.475). Higher Wmax/BM1, but not Wmax/LM1.13, was associated with lower insulin and HOMA-IR in children with higher BF%. Children with higher BF% and who had lower levels of MVPA or higher levels of sedentary time had the highest insulin and HOMA-IR.
Conclusion Children with higher BF% together with less MVPA or higher levels of sedentary time had the highest insulin and HOMA-IR. CRF appropriately controlled for body size and composition using LM was not related to insulin resistance among children.


Keywords: children (age groups); physical activeness; physical training; insulin resistance; diabetes; body composition

Free keywords: diabetes; youth; exercise; performance; insulin; insulin sensitivity; obesity


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2020

Preliminary JUFO rating: 3


Last updated on 2020-18-08 at 13:35