A1 Journal article (refereed)
Acute responses of comprehensive gonadosteroids and corticosteroids to resistance exercise before and after 10 weeks of supervised strength training (2020)


Walker, S.; Häkkinen, K.; Newton, R. U.; Markworth, J. F.; Pundir, S.; Haff, G. G.; Cameron-Smith, D.; Blazevich, A. J. (2020). Acute responses of comprehensive gonadosteroids and corticosteroids to resistance exercise before and after 10 weeks of supervised strength training. Experimental Physiology, 105 (3), 438-448. DOI: 10.1113/EP087995


JYU authors or editors


Publication details

All authors or editors: Walker, S.; Häkkinen, K.; Newton, R. U.; Markworth, J. F.; Pundir, S.; Haff, G. G.; Cameron-Smith, D.; Blazevich, A. J.

Journal or series: Experimental Physiology

ISSN: 0958-0670

eISSN: 1469-445X

Publication year: 2020

Volume: 105

Issue number: 3

Pages range: 438-448

Publisher: Wiley-Blackwell Publishing Ltd.

Publication country: United Kingdom

Publication language: English

DOI: http://doi.org/10.1113/EP087995

Open Access: Publication channel is not openly available

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/67084


Abstract

Resistance training is a potent stimulus for muscle growth and steroid hormones are known to play a role in this adaptation. However, very little is known about the acute exercise‐induced gonadosteroid and corticosteroid hormone responses, including key smaller‐concentration intermediate hormones. The present study determined the acute responses of these steroid hormone families using quantitative UHPLC mass spectrometry (MS) following resistance exercise in strength‐trained men. Venous and fingertip blood was drawn pre‐, mid‐, 5 min post‐ and 15 min post‐resistance exercise, both before and after 10 weeks of supervised resistance training. The experimental resistance exercise sessions consisted of 3 sets of 10 repetitions in the bilateral leg press and 3 sets of 10 repetitions in the unilateral knee extension with 2 and 1 min recovery between sets, respectively. Statistically significant (P < 0.05) increases in the concentration of hormones in the gonadosteroid (including; dehydroepiandrosterone (DHEA), androstenedione, testosterone, estrone) and the corticosteroid (including; cortisol, corticosterone and cortisone) families were demonstrated after both experimental resistance exercise sessions, irrespective of training status. Correlation analyses revealed relationships between: 1) DHEA and androstenedione, 2) DHEA and cortisol, 3) androstenedione and estrone, and 4) 11‐deoxycortisol and cortisol. Testosterone appears to acutely increase independently of other intermediary hormones following resistance exercise. In conclusion, smaller‐concentration intermediary gonadosteroids (e.g. estrone) and corticosteroids (e.g. corticosterone) respond robustly to resistance exercise in strength‐trained men, although it seems that testosterone concentrations are regulated by factors other than the availability of precursor hormones and changes in plasma volume.


Keywords: strength training; hormonal effects; hormones; steroids; estrogens; testosterone; mass spectrometry

Free keywords: 11‐deoxycortisol; androstenedione; cortisol; DHEA; estrogen; hormones; mass spectroscopy; resistance training; testosterone; UHPLC mass spectroscopy


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2020

Preliminary JUFO rating: 1


Last updated on 2020-18-08 at 13:22