A2 Katsausartikkeli tieteellisessä aikausilehdessä
Exercise treatment effect modifiers in persistent low back pain : an individual participant data meta-analysis of 3514 participants from 27 randomised controlled trials (2020)
Hayden, J. A., Wilson, M. N., Stewart, S., Cartwright, J. L., Smith, A. O., Riley, R. D., van Tulder, M., Bendix, T., Cecchi, F., Costa, L. O. P., Dufour, N., Ferreira, M. L., Foster, N. E., Gudavalli, M. R., Hartvigsen, J., Helmhout, P., Kool, J., Koumantakis, G. A., Kovacs, F. M., . . . Yeung, E. W. (2020). Exercise treatment effect modifiers in persistent low back pain : an individual participant data meta-analysis of 3514 participants from 27 randomised controlled trials. British Journal of Sports Medicine, 54, 1277-1278. https://doi.org/10.1136/bjsports-2019-101205
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Hayden, Jill A.; Wilson, Maria N.; Stewart, Samuel; Cartwright, Jennifer L.; Smith, Andrea O.; Riley, Richard D.; van Tulder, Maurits; Bendix, Tom; Cecchi, Francesca; Costa, Leonardo O. P.; et al.
Lehti tai sarja: British Journal of Sports Medicine
ISSN: 0306-3674
eISSN: 1473-0480
Julkaisuvuosi: 2020
Volyymi: 54
Artikkelin sivunumerot: 1277-1278
Kustantaja: BMJ Publishing Group Ltd.; British Association of Sport and Exercise Medicine
Julkaisumaa: Britannia
Julkaisun kieli: englanti
DOI: https://doi.org/10.1136/bjsports-2019-101205
Julkaisun avoin saatavuus: Ei avoin
Julkaisukanavan avoin saatavuus:
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/73970
Lisätietoja: Protocol publication: https://doi.org/10.1186/2046-4053-1-64
Tiivistelmä
Methods: In parallel with a Cochrane review update, we requested individual participant data (IPD) from high-quality randomised clinical trials of adults with our two primary outcomes of interest, pain and functional limitations, and calculated global recovery. We compiled a master data set including baseline participant characteristics, exercise and comparison characteristics, and outcomes at short-term, moderate-term and long-term follow-up. We conducted descriptive analyses and one-stage IPD meta-analysis using multilevel mixed-effects regression of the overall treatment effect and prespecified potential treatment effect modifiers.
Results: We received IPD for 27 trials (3514 participants). For studies included in this analysis, compared with no treatment/usual care, exercise therapy on average reduced pain (mean effect/100 (95% CI) −10.7 (−14.1 to –7.4)), a result compatible with a clinically important 20% smallest worthwhile effect. Exercise therapy reduced functional limitations with a clinically important 23% improvement (mean effect/100 (95% CI) −10.2 (−13.2 to –7.3)) at short-term follow-up. Not having heavy physical demands at work and medication use for low back pain were potential treatment effect modifiers—these were associated with superior exercise outcomes relative to non-exercise comparisons. Lower body mass index was also associated with better outcomes in exercise compared with no treatment/usual care. This study was limited by inconsistent availability and measurement of participant characteristics.
Conclusions: This study provides potentially useful information to help treat patients and design future studies of exercise interventions that are better matched to specific subgroups.
YSO-asiasanat: selkäsairaudet; krooninen kipu; kuntoutus; liikuntahoito; meta-analyysi
Vapaat asiasanat: exercise rehabilitation; intervention effectiveness; lower back; meta-analysis
Liittyvät organisaatiot
OKM-raportointi: Kyllä
Raportointivuosi: 2020
JUFO-taso: 2
