A1 Journal article (refereed)
Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat (2020)
Paasonen, J., Laakso, H., Pirttimäki, T., Stenroos, P., Salo, R. A., Zhurakovskaya, E., Lehto, L. J., Tanila, H., Garwood, M., Michaeli, S., Idiyatullin, D., Mangia, S., & Gröhn, O. (2020). Multi-band SWIFT enables quiet and artefact-free EEG-fMRI and awake fMRI studies in rat. NeuroImage, 206, Article 116338. https://doi.org/10.1016/j.neuroimage.2019.116338
JYU authors or editors
Publication details
All authors or editors: Paasonen, Jaakko; Laakso, Hanne; Pirttimäki, Tiina; Stenroos, Petteri; Salo, Raimo A.; Zhurakovskaya, Ekaterina; Lehto, Lauri J.; Tanila, Heikki; Garwood, Michael; Michaeli, Shalom; et al.
Journal or series: NeuroImage
ISSN: 1053-8119
eISSN: 1095-9572
Publication year: 2020
Volume: 206
Article number: 116338
Publisher: Elsevier
Publication country: United States
Publication language: English
DOI: https://doi.org/10.1016/j.neuroimage.2019.116338
Publication open access: Openly available
Publication channel open access: Open Access channel
Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/67446
Abstract
Functional magnetic resonance imaging (fMRI) studies in animal models provide invaluable information regarding normal and abnormal brain function, especially when combined with complementary stimulation and recording techniques. The echo planar imaging (EPI) pulse sequence is the most common choice for fMRI investigations, but it has several shortcomings. EPI is one of the loudest sequences and very prone to movement and susceptibility-induced artefacts, making it suboptimal for awake imaging. Additionally, the fast gradient-switching of EPI induces disrupting currents in simultaneous electrophysiological recordings. Therefore, we investigated whether the unique features of Multi-Band SWeep Imaging with Fourier Transformation (MB-SWIFT) overcome these issues at a high 9.4 T magnetic field, making it a potential alternative to EPI. MB-SWIFT had 32-dB and 20-dB lower peak and average sound pressure levels, respectively, than EPI with typical fMRI parameters. Body movements had little to no effect on MB-SWIFT images or functional connectivity analyses, whereas they severely affected EPI data. The minimal gradient steps of MB-SWIFT induced significantly lower currents in simultaneous electrophysiological recordings than EPI, and there were no electrode-induced distortions in MB-SWIFT images. An independent component analysis of the awake rat functional connectivity data obtained with MB-SWIFT resulted in near whole-brain level functional parcellation, and simultaneous electrophysiological and fMRI measurements in isoflurane-anesthetized rats indicated that MB-SWIFT signal is tightly linked to neuronal resting-state activity. Therefore, we conclude that the MB-SWIFT sequence is a robust preclinical brain mapping tool that can overcome many of the drawbacks of conventional EPI fMRI at high magnetic fields.
Keywords: functional magnetic resonance imaging; animal disease models
Free keywords: awake; electroencephalography; functional connectivity; functional magnetic resonance imaging; rats
Contributing organizations
Ministry reporting: Yes
Reporting Year: 2020
JUFO rating: 2