A1 Journal article (refereed)
Infection Load and Prevalence of Novel Viruses Identified from the Bank Vole Do Not Associate with Exposure to Environmental Radioactivity (2020)

Kesäniemi, J., Lavrinienko, A., Tukalenko, E., Mappes, T., Watts, P. C., & Jurvansuu, J. (2020). Infection Load and Prevalence of Novel Viruses Identified from the Bank Vole Do Not Associate with Exposure to Environmental Radioactivity. Viruses, 12(1), Article 44. https://doi.org/10.3390/v12010044

JYU authors or editors

Publication details

All authors or editors: Kesäniemi, Jenni; Lavrinienko, Anton; Tukalenko, Eugene; Mappes, Tapio; Watts, Phillip C.; Jurvansuu, Jaana

Journal or series: Viruses

eISSN: 1999-4915

Publication year: 2020

Volume: 12

Issue number: 1

Article number: 44

Publisher: MDPI AG

Publication country: Switzerland

Publication language: English

DOI: https://doi.org/10.3390/v12010044

Publication open access: Openly available

Publication channel open access: Open Access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/67315

Abstract

Bank voles (Myodes glareolus) are host to many zoonotic viruses. As bank voles inhabiting areas contaminated by radionuclides show signs of immunosuppression, resistance to apoptosis, and elevated DNA repair activity, we predicted an association between virome composition and exposure to radionuclides. To test this hypothesis, we studied the bank vole virome in samples of plasma derived from animals inhabiting areas of Ukraine (contaminated areas surrounding the former nuclear power plant at Chernobyl, and uncontaminated areas close to Kyiv) that differed in level of environmental radiation contamination. We discovered four strains of hepacivirus and four new virus sequences: two adeno-associated viruses, an arterivirus, and a mosavirus. However, viral prevalence and viral load, and the ability to cause a systemic infection, was not dependent on the level of environmental radiation.

Keywords: Clethrionomys glareolus; viruses; radiobiology; sequencing

Free keywords: plasma viromes; bank vole; adeno-associated virus; mosavirus; arterivirus; environmental radiation; next-generation sequencing

Contributing organizations

Related projects

Ministry reporting: Yes

VIRTA submission year: 2020

JUFO rating: 1