A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Observe while it happens : catching photoactive proteins in the act with non-adiabatic molecular dynamics simulations (2020)

Groenhof, G., Modi, V., & Morozov, D. (2020). Observe while it happens : catching photoactive proteins in the act with non-adiabatic molecular dynamics simulations. Current Opinion in Structural Biology, 61, 106-112. https://doi.org/10.1016/j.sbi.2019.12.013

JYU-tekijät tai -toimittajat

Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Groenhof, Gerrit; Modi, Vaibhav; Morozov, Dmitry

Lehti tai sarja: Current Opinion in Structural Biology

ISSN: 0959-440X

eISSN: 1879-033X

Julkaisuvuosi: 2020

Volyymi: 61

Artikkelin sivunumerot: 106-112

Kustantaja: Elsevier Ltd.

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1016/j.sbi.2019.12.013

Julkaisun avoin saatavuus: Avoimesti saatavilla

Julkaisukanavan avoin saatavuus: Osittain avoin julkaisukanava

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/68788

Tiivistelmä

Organisms use photo-receptors to react to light. The first step is usually the absorption of a photon by a prosthetic group embedded inside the photo-receptor, often a conjugated chromophore. The electronic changes in the chromophore induced by photo-absorption can trigger a cascade of structural or chemical transformations that culminate into a response to light. Understanding how these proteins have evolved to mediate their activation process has remained challenging because the required time and spacial resolutions are notoriously difficult to achieve experimentally. Therefore, mechanistic insights into photoreceptor activation have been predominantly obtained with computer simulations. Here we briefly outline the challenges associated with such computations and review the progress made in this field.

YSO-asiasanat: proteiinit; molekyylibiologia

Vapaat asiasanat: photoactive proteins; molecular biology

Liittyvät organisaatiot

OKM-raportointi: Kyllä

Raportointivuosi: 2020

JUFO-taso: 1