A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Muscle and bone mass in middle‐aged women : role of menopausal status and physical activity (2020)
Sipilä, S., Törmäkangas, T., Sillanpää, E., Aukee, P., Kujala, U. M., Kovanen, V., & Laakkonen, E. K. (2020). Muscle and bone mass in middle‐aged women : role of menopausal status and physical activity. Journal of Cachexia, Sarcopenia and Muscle, 11(3), 698-709. https://doi.org/10.1002/jcsm.12547
JYU-tekijät tai -toimittajat
Julkaisun tiedot
Julkaisun kaikki tekijät tai toimittajat: Sipilä, Sarianna; Törmäkangas, Timo; Sillanpää, Elina; Aukee, Pauliina; Kujala, Urho M.; Kovanen, Vuokko; Laakkonen, Eija K.
Lehti tai sarja: Journal of Cachexia, Sarcopenia and Muscle
ISSN: 2190-5991
eISSN: 2190-6009
Julkaisuvuosi: 2020
Volyymi: 11
Lehden numero: 3
Artikkelin sivunumerot: 698-709
Kustantaja: Wiley-VCH Verlag
Julkaisumaa: Saksa
Julkaisun kieli: englanti
DOI: https://doi.org/10.1002/jcsm.12547
Julkaisun avoin saatavuus: Avoimesti saatavilla
Julkaisukanavan avoin saatavuus: Kokonaan avoin julkaisukanava
Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/67742
Tiivistelmä
Methods. Data from the Estrogen Regulation of Muscle Apoptosis study were utilized. In total, 1393 women aged 47–55 years were assigned to premenopausal, early perimenopausal, late perimenopausal, and postmenopausal groups based on folliclestimulating hormone concentration and bleeding diaries. Of them, 897 were scanned for ALM and femoral neck BMD by dual-energy X-ray absorptiometry and ALMI (ALM/height2 ) and neck T scores calculated. Current level of leisure-time physical activity was estimated by a validated self-report questionnaire and categorized as sedentary, low, medium, and high.
Results. Appendicular lean mass, appendicular lean mass index, femoral neck bone mineral density, and and T score showed a significant linear declining trend across all four menopausal groups. Compared with the postmenopausal women, the premenopausal women showed greater ALM (18.2, SD 2.2 vs. 17.8, SD 2.1, P < 0.001), ALMI (6.73, SD 0.64 vs. 6.52, SD 0.62, P < 0.001), neck BMD (0.969, SD 0.117 vs. 0.925, SD 0.108, P < 0.001), and T score ( 0.093, SD 0.977 vs 0.459, SD 0.902, P < 0.001). After adjusting for potential confounding pathways, a higher level of physical activity was associated with greater ALM among the premenopausal [β = 0.171; confidence interval (CI) 95% 0.063–0.280], late perimenopausal (β = 0.289; CI 95% 0.174–0.403), and postmenopausal (β=0.278; CI 95% 0.179–0.376) women. The positive association between femoral neck BMD and level of physical activity was significant only among the late perimenopausal women (β = 0.227; CI 95% 0.097– 0.356).
Conclusions. Skeletal muscle and bone losses were associated with the menopausal transition. A higher level of physical activity during the different menopausal phases was beneficial, especially for skeletal muscle. Menopause-related hormonal changes predispose women to sarcopenia and osteoporosis and further to mobility disability and fall-related fractures in later life. New strategies are needed to promote physical activity among middle-aged women. Longitudinal studies are needed to confirm these results.
YSO-asiasanat: lihasmassa; lihassurkastumasairaudet; luu; osteoporoosi; keski-ikä; vaihdevuodet; naiset; sukupuolihormonit
Vapaat asiasanat: sarcopenia; osteoporosis; midlife; female; sex hormones
Liittyvät organisaatiot
Hankkeet, joissa julkaisu on tehty
- Estrogeeni-välitteinen apoptoosin säätely lihaksen ikääntymismuutosten ja sarkopenian säätelijänä
- Kovanen, Vuokko
- Suomen Akatemia
- Keski-ikäisten naisten metabolisten toimintahäiriöiden riski: Fyysinen aktiivisuus sekä systeeminen ja intrakriininen estrogeeni ja mikroRNAt riskin mediaattoreina
- Laakkonen, Eija
- Suomen Akatemia
Liittyvät tutkimusaineistot
OKM-raportointi: Kyllä
Raportointivuosi: 2020
JUFO-taso: 2