A1 Journal article (refereed)
Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms (2020)


Noerman, Stefania; Klåvus, Anton; Järvelä-Reijonen, Elina; Karhunen, Leila; Auriola, Seppo; Korpela, Riitta; Lappalainen, Raimo; Kujala, Urho M.; Puttonen, Sampsa; Kolehmainen, Marjukka et al. (2020). Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms. Scientific Reports, 10, 2143. DOI: 10.1038/s41598-020-59051-x


JYU authors or editors


Publication details

All authors or editors: Noerman, Stefania; Klåvus, Anton; Järvelä-Reijonen, Elina; Karhunen, Leila; Auriola, Seppo; Korpela, Riitta; Lappalainen, Raimo; Kujala, Urho M.; Puttonen, Sampsa; Kolehmainen, Marjukka; et al.

Journal or series: Scientific Reports

eISSN: 2045-2322

Publication year: 2020

Volume: 10

Article number: 2143

Publisher: Nature Publishing Group

Publication country: United Kingdom

Publication language: English

DOI: https://doi.org/10.1038/s41598-020-59051-x

Open Access: Publication published in an open access channel

Publication is parallel published (JYX): https://jyx.jyu.fi/handle/123456789/67792


Abstract

Psychological stress is a suggested risk factor of metabolic disorders, but molecular mediators are not well understood. We investigated the association between the metabolic profiles of fasting plasma and the improvement of psychological well-being using non-targeted liquid chromatography-mass spectrometry (LC-MS) platform. The metabolic profiles of volunteers participating in the face-to-face intervention group (n = 60) in a randomised lifestyle intervention were compared to ones of controls (n = 64) between baseline and 36-week follow-up. Despite modest differences in metabolic profile between groups, we found associations between phosphatidylcholines (PCs) and several parameters indicating stress, adiposity, relaxation, and recovery. The relief of heart-rate-variability-based stress had positive, while improved indices of recovery and relaxation in the intervention group had an inverse association with the reduction of e.g. lysophosphatidylcholines (LPC). Interleukin-1 receptor antagonist and adiposity correlated positively with the suppressed PCs and negatively with the elevated plasmalogens PC(P-18:0/22:6) and PC(P-18:0/20:4). Also, we found changes in an unknown class of lipids over time regardless of the intervention groups, which also correlated with physiological and psychological markers of stress. The associations between lipid changes with some markers of psychological wellbeing and body composition may suggest the involvement of these lipids in the shared mechanisms between psychological and metabolic health.


Keywords: metabolism; metabolic disorders; stress (biological phenomena); mental well-being; markers; lipids

Free keywords: metabolomics; predictive markers


Contributing organizations


Ministry reporting: Yes

Reporting Year: 2020

Preliminary JUFO rating: 1


Last updated on 2020-18-08 at 13:29