A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms (2020)


Noerman, Stefania; Klåvus, Anton; Järvelä-Reijonen, Elina; Karhunen, Leila; Auriola, Seppo; Korpela, Riitta; Lappalainen, Raimo; Kujala, Urho M.; Puttonen, Sampsa; Kolehmainen, Marjukka et al. (2020). Plasma lipid profile associates with the improvement of psychological well-being in individuals with perceived stress symptoms. Scientific Reports, 10, 2143. DOI: 10.1038/s41598-020-59051-x


JYU-tekijät tai -toimittajat


Julkaisun tiedot

Julkaisun kaikki tekijät tai toimittajat: Noerman, Stefania; Klåvus, Anton; Järvelä-Reijonen, Elina; Karhunen, Leila; Auriola, Seppo; Korpela, Riitta; Lappalainen, Raimo; Kujala, Urho M.; Puttonen, Sampsa; Kolehmainen, Marjukka; et al.

Lehti tai sarja: Scientific Reports

eISSN: 2045-2322

Julkaisuvuosi: 2020

Volyymi: 10

Artikkelinumero: 2143

Kustantaja: Nature Publishing Group

Julkaisumaa: Britannia

Julkaisun kieli: englanti

DOI: https://doi.org/10.1038/s41598-020-59051-x

Avoin saatavuus: Open access -julkaisukanavassa ilmestynyt julkaisu

Julkaisukanavan avoin saatavuus:

Julkaisun avoin saatavuus:

Julkaisu on rinnakkaistallennettu (JYX): https://jyx.jyu.fi/handle/123456789/67792


Tiivistelmä

Psychological stress is a suggested risk factor of metabolic disorders, but molecular mediators are not well understood. We investigated the association between the metabolic profiles of fasting plasma and the improvement of psychological well-being using non-targeted liquid chromatography-mass spectrometry (LC-MS) platform. The metabolic profiles of volunteers participating in the face-to-face intervention group (n = 60) in a randomised lifestyle intervention were compared to ones of controls (n = 64) between baseline and 36-week follow-up. Despite modest differences in metabolic profile between groups, we found associations between phosphatidylcholines (PCs) and several parameters indicating stress, adiposity, relaxation, and recovery. The relief of heart-rate-variability-based stress had positive, while improved indices of recovery and relaxation in the intervention group had an inverse association with the reduction of e.g. lysophosphatidylcholines (LPC). Interleukin-1 receptor antagonist and adiposity correlated positively with the suppressed PCs and negatively with the elevated plasmalogens PC(P-18:0/22:6) and PC(P-18:0/20:4). Also, we found changes in an unknown class of lipids over time regardless of the intervention groups, which also correlated with physiological and psychological markers of stress. The associations between lipid changes with some markers of psychological wellbeing and body composition may suggest the involvement of these lipids in the shared mechanisms between psychological and metabolic health.


YSO-asiasanat: aineenvaihdunta; aineenvaihduntahäiriöt; stressi; henkinen hyvinvointi; markkerit; lipidit

Vapaat asiasanat: metabolomics; predictive markers


Liittyvät organisaatiot


OKM-raportointi: Kyllä

Raportointivuosi: 2020

Alustava JUFO-taso: 1


Viimeisin päivitys 2020-18-08 klo 13:29